Electrophysiological assessment of auditory stimulus-specific plasticity in schizophrenia.
Electrophysiological assessment of auditory stimulus-specific plasticity in schizophrenia.
复制标题
DOI：
10.1016/j.biopsych.2011.12.016
复制
发表时间：
2012-03-15
影响因子：
10.6
通讯作者：
Spencer KM
中科院分区：
文献类型：
--
作者：
Mears RP;Spencer KM
神经可塑性的破坏可能是精神分裂症神经基础的一个重要方面。我们采用事件相关脑电位（ERP）检测慢性精神分裂症患者（SZ）和健康对照者（HC）在听觉条件反射后的神经可塑性。受试者（15名HC，14名SZ）在听觉强直刺激（前/后阻滞）之前和之后的脑电图记录期间执行听觉oddball任务。每个古怪的块由1000 Hz和1500 Hz标准和400 Hz目标组成。在强直条件反射期间，1000 Hz的音调以11 Hz的频率呈现2.4 min。我们分析了标准试验，比较了强直刺激（1000 Hz音调：TS+）和非强直刺激（1500 Hz音调：TS-）在后阻滞中诱发的ERP与来自前阻滞的ERP（平均为基线ERP）。在HC的后阻滞1中，TS+音调在右颞电极处诱发相对于基线的负移（60-350 msec）。在SZ中未发现破伤风前/后效应。在HC的后阻滞2中，TS+音在双侧额叶电极处诱发正移位（200-300 msec）。在SZ，TS+音诱发右额颞电极的正移（100-400毫秒）。在两个受试者组中均未发现TS-音的破伤风前/破伤风后效应。在SZ中，右颞后阻滞1和2效应相关，表明这些效应的表达存在权衡。这些结果表明，刺激特异性听觉神经可塑性异常的精神分裂症。电生理学评估的刺激特异性可塑性可能会产生新的药物治疗精神分裂症的目标。
Disrupted neuroplasticity may be an important aspect of the neural basis of schizophrenia. We used event-related brain potentials (ERPs) to assay neuroplasticity after auditory conditioning in chronic schizophrenia patients (SZ) and matched healthy control subjects (HC). Subjects (15 HC, 14 SZ) performed an auditory oddball task during electroencephalogram recording before and after auditory tetanic stimulation (Pre/Post Blocks). Each oddball block consisted of 1000-Hz and 1500-Hz standards and 400-Hz targets. During tetanic conditioning, 1000-Hz tones were presented at 11 Hz for 2.4 min. We analyzed the standard trials, comparing the ERPs evoked by the tetanized stimuli (1000 Hz tones: TS+) and untetanized stimuli (1500 Hz tones: TS−) in the Post Blocks with ERPs from the Pre Blocks (averaged into Baseline ERPs). In Post Block 1 in HC, TS+ tones evoked a negative shift (60–350 msec) at right temporal electrodes relative to Baseline. No pre-/post-tetanus effects were found in SZ. In Post Block 2 in HC, TS+ tones evoked a positive shift (200–300 msec) at bilateral frontal electrodes. In SZ, TS+ tones evoked a positive shift (100–400 msec) at right frontotemporal electrodes. No pre-/post-tetanus effects were found in either subject group for the TS− tones. The right temporal Post Block 1 and 2 effects were correlated in SZ, suggesting a trade-off in the expression of these effects. These results suggest that stimulus-specific auditory neuroplasticity is abnormal in schizophrenia. The electrophysiologic assessment of stimulus-specific plasticity may yield novel targets for drug treatment in schizophrenia.
登录
查看更多内容
影响因子：
3.7
作者：
Frantseva, Marina V.;Fitzgerald, Paul B.;Daskalakis, Zafiris J.
通讯作者：
Daskalakis, Zafiris J.
影响因子：
3.9
作者：
Kirk, Ian J.;McNair, Nicolas A.;Teyler, Timothy J.
通讯作者：
Teyler, Timothy J.
影响因子：
3.7
作者：
Ben-David, Boaz M.;Campeanu, Sandra;Alain, Claude
通讯作者：
Alain, Claude
影响因子：
3.4
作者：
Krystal, JH;D'Souza, DC;Hoffman, R
通讯作者：
Hoffman, R
影响因子：
5.5
作者：
BLISS, TVP;LOMO, T
通讯作者：
LOMO, T