Using routinely collected data to understand and predict adverse outcomes in opioid agonist treatment: Protocol for the Opioid Agonist Treatment Safety (OATS) Study.
Using routinely collected data to understand and predict adverse outcomes in opioid agonist treatment: Protocol for the Opioid Agonist Treatment Safety (OATS) Study.
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DOI：
10.1136/bmjopen-2018-025204
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发表时间：
2018-08-05
期刊：
影响因子：
2.9
通讯作者：
Degenhardt L
中科院分区：
文献类型：
--
作者：
Larney S;Hickman M;Fiellin DA;Dobbins T;Nielsen S;Jones NR;Mattick RP;Ali R;Degenhardt L
North America is amid an opioid use epidemic. Opioid agonist treatment (OAT) effectively reduces extramedical opioid use and related harms. As with all pharmacological treatments, there are risks associated with OAT, including fatal overdose. There is a need to better understand risk for adverse outcomes during and after OAT, and for innovative approaches to identifying people at greatest risk of adverse outcomes. The Opioid Agonist Treatment and Safety study aims to address these questions so as to inform the expansion of OAT in the USA. This is a retrospective cohort study using linked, routinely collected health data for all people seeking OAT in New South Wales, Australia, between 2001 and 2017. Linked data include hospitalisation, emergency department presentation, mental health diagnoses, incarceration and mortality. We will use standard regression techniques to model the magnitude and risk factors for adverse outcomes (eg, mortality, unplanned hospitalisation and emergency department presentation, and unplanned treatment cessation) during and after OAT, and machine learning approaches to develop a risk-prediction model. This study has been approved by the Population and Health Services Research Ethics Committee (2018HRE0205). Results will be reported in accordance with the REporting of studies Conducted using Observational Routinely-collected health Data statement.
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影响因子：
64.3
作者：
Kimber, Jo;Larney, Sarah;Degenhardt, Louisa
通讯作者：
Degenhardt, Louisa
影响因子：
120.7
作者：
Han, Beth;Compton, Wilson M.;Cai, Rong
通讯作者：
Cai, Rong
DOI：
10.1111/add.14188
发表时间：
2018-08
期刊：
Addiction (Abingdon, England)
影响因子：
--
作者：
Hickman M;Steer C;Tilling K;Lim AG;Marsden J;Millar T;Strang J;Telfer M;Vickerman P;Macleod J
通讯作者：
Macleod J
影响因子：
5.5
作者：
Kampman K;Jarvis M
通讯作者：
Jarvis M
影响因子：
2.6
作者：
Karanges, Emily A.;Buckley, Nicholas A.;Pearson, Sallie-Anne
通讯作者：
Pearson, Sallie-Anne