Blood vessel rupture by cavitation.
Blood vessel rupture by cavitation.
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DOI：
10.1007/s00240-010-0302-5
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发表时间：
2010-08
影响因子：
--
通讯作者：
Matula, Thomas J.
中科院分区：
文献类型：
--
作者：
Chen, Hong;Brayman, Andrew A.;Bailey, Michael R.;Matula, Thomas J.
空化被认为是冲击波碎石治疗中血管破裂的一种机制。然而，空化是如何引起血管破裂的仍然未知。本文建立高速显微摄影系统，直接观察离体大鼠肠系膜血管内气泡的动态变化。血管破裂与观察到的气泡动力学相关，通过成像检查气泡外渗和染料泄漏。高速图像显示，气泡膨胀可引起血管扩张，气泡破裂可导致血管内陷。还观察到液体射流的形成。我们的研究结果表明，血管扩张、内陷和液体喷射这三种机制都可能导致血管破裂。
Cavitation is thought to be one mechanism for vessel rupture during shock wave lithotripsy treatment. However, just how cavitation induces vessel rupture remains unknown. In this work, a high-speed photomicrography system was set up to directly observe the dynamics of bubbles inside blood vessels in ex vivo rat mesenteries. Vascular rupture correlating to observed bubble dynamics were examined by imaging bubble extravasation and dye leakage. The high-speed images show that bubble expansion can cause vessel distention, and bubble collapse can lead to vessel invagination. Liquid jets were also observed to form. Our results suggest that all three mechanisms, vessel distention, invagination and liquid jets, can contribute to vessel rupture.
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影响因子：
2.4
作者：
Caskey, Charles F.;Stieger, Susanne M.;Ferrara, Katherine W.
通讯作者：
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影响因子：
2.9
作者：
Zhong, P;Zhou, YF;Zhu, SL
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影响因子：
6.6
作者：
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通讯作者：
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影响因子：
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作者：
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通讯作者：
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