Recombinant inbred systems can advance research in behavioral ecology.

Recombinant inbred systems can advance research in behavioral ecology.
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DOI:
10.3389/fgene.2012.00198
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发表时间:
2012
影响因子:
3.7
通讯作者:
Hager R
Hager R
中科院分区:
生物学3区
文献类型:
--
作者:
Gini B;Hager R

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重组近交 (RI) 系统(例如 BXD 小鼠家族)代表的群体具有确定的遗传结构和变异,与自然群体相似。随着新型 RI 系和联合分析表型、基因序列和表达数据的复杂方法的发展,BXD 等 RI 系统成为推动行为生态学领域发展的及时而强大的工具。后者传统上关注功能问题,例如行为的适应性价值,但很大程度上忽略了潜在的遗传学和机制。从这个角度来看,我们认为使用 RI 系统来解决行为生态学和进化生物学中的问题具有推进这些领域研究的巨大潜力。我们概述了关键问题以及如何使用 RI 系统,特别是 BXD 来解决这些问题。分析在不同实验室和不同时间进行的研究的遗传和表型数据的独特机会是 RI 系统的一个关键优势,并且可能有助于更好地理解适应性表型如何由遗传和环境因素产生。
Recombinant inbred (RI) systems such as the BXD mouse family represent a population with defined genetic architecture and variation that approximates those of natural populations. With the development of novel RI lines and sophisticated methods that conjointly analyze phenotype, gene sequence, and expression data, RI systems such as BXD are a timely and powerful tool to advance the field of behavioral ecology. The latter traditionally focused on functional questions such as the adaptive value of behavior but largely ignored underlying genetics and mechanisms. In this perspective, we argue that using RI systems to address questions in behavioral ecology and evolutionary biology has great potential to advance research in these fields. We outline key questions and how they can be tackled using RI systems and BXD in particular. The unique opportunity to analyze genetic and phenotypic data from studies conducted in different laboratories and at different times is a key benefit of RI systems and may lead the way to a better understanding of how adaptive phenotypes arise from genetic and environmental factors.
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