An overview of APP processing enzymes and products.
An overview of APP processing enzymes and products.
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DOI：
10.1007/s12017-009-8104-z
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发表时间：
2010-03
影响因子：
3.5
通讯作者：
Gleichmann, Marc
中科院分区：
文献类型：
--
作者：
Chow, Vivian W.;Mattson, Mark P.;Wong, Philip C.;Gleichmann, Marc
通过β-淀粉样前体蛋白（APP）的酶切产生淀粉样β-肽（Aβ）一直是阿尔茨海默病（AD）研究的核心。虽然β-分泌酶和γ-分泌酶介导的Aβ产生的基本过程是教科书知识，但近年来Aβ和其他裂解产物的新方面已经出现。我们对参与APP蛋白水解的酶的理解也有了极大的提高。所有这些发现都有助于更全面地理解APP的加工过程以及其分泌的和细胞内的蛋白质产物的生理和病理作用。理解APP加工过程对于任何旨在降低AD中Aβ水平的治疗策略都很重要。在这篇综述中，我们简要描述了目前对参与APP加工的酶、不同加工模式产生的裂解产物以及这些裂解产物的潜在功能的理解状况。
The generation of amyloid β-peptide (Aβ) by enzymatic cleavages of the β-amyloid precursor protein (APP) has been at the center of Alzheimer’s disease (AD) research. While the basic process of β- and γ-secretase-mediated generation of Aβ is text book knowledge, new aspects of Aβ and other cleavage products have emerged in recent years. Also our understanding of the enzymes involved in APP proteolysis has increased dramatically. All of these discoveries contribute to a more complete understanding of APP processing and the physiological and pathological roles of its secreted and intracellular protein products. Understanding APP processing is important for any therapeutic strategy aimed at reducing Aβ levels in AD. In this review we provide a concise description of the current state of understanding the enzymes involved in APP processing, the cleavage products generated by different processing patterns, and the potential functions of those cleavage products.
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