Natural Compound Resveratrol Attenuates TNF-Alpha-Induced Vascular Dysfunction in Mice and Human Endothelial Cells: The Involvement of the NF-κB Signaling Pathway.
Natural Compound Resveratrol Attenuates TNF-Alpha-Induced Vascular Dysfunction in Mice and Human Endothelial Cells: The Involvement of the NF-κB Signaling Pathway.
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DOI：
10.3390/ijms222212486
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发表时间：
2021-11-19
影响因子：
5.6
通讯作者：
Jia Z
中科院分区：
文献类型：
--
作者：
Nallasamy P;Kang ZY;Sun X;Anandh Babu PV;Liu D;Jia Z
白藜芦醇是葡萄和红葡萄酒中的一种天然化合物，由于潜在的心血管相关健康益处而引起了人们的关注。然而，在生理上可以达到的浓度下，它对血管炎症的影响在很大程度上是未知的。在这项研究中，低至1μm的白藜芦醇抑制肿瘤坏死因子-α诱导的单核细胞与人EA.hy926内皮细胞的黏附，这是动脉粥样硬化发生和发展的关键事件。低浓度白藜芦醇(0.2~2μm)还可显著降低肿瘤坏死因子-α刺激的单核细胞黏附分子和心血管斑块形成细胞因子MCP-1/CCL2和ICAM-1mRNA的表达。此外，白藜芦醇还可抑制肿瘤坏死因子-α诱导的内皮细胞IκB-α降解和随后的核转位。在动物研究中，饮食中添加白藜芦醇显著降低了由肿瘤坏死因子-α引起的循环黏附分子和细胞因子水平、单核细胞与小鼠主动脉内皮细胞的黏附、小鼠主动脉F4/80阳性巨噬细胞和血管细胞黏附分子-1的表达，并恢复了肿瘤坏死因子-α治疗引起的主动脉弹性蛋白纤维的断裂。动物研究还证实，白藜芦醇在体内阻断了核因子-κB的激活。总之，生理可达浓度的白藜芦醇在体外和体内均对肿瘤坏死因子-α诱导的血管内皮细胞炎症有保护作用。白藜芦醇的抗炎作用可能与其下调NF-κB途径有关。
Resveratrol, a natural compound in grapes and red wine, has drawn attention due to potential cardiovascular-related health benefits. However, its effect on vascular inflammation at physiologically achievable concentrations is largely unknown. In this study, resveratrol in concentrations as low as 1 μm suppressed TNF-α-induced monocyte adhesion to human EA.hy926 endothelial cells (ECs), a key event in the initiation and development of atherosclerosis. Low concentrations of resveratrol (0.25–2 μm) also significantly attenuated TNF-α-stimulated mRNA expressions of MCP-1/CCL2 and ICAM-1, which are vital mediators of EC-monocyte adhesion molecules and cytokines for cardiovascular plaque formation. Additionally, resveratrol diminished TNF-α-induced IκB-α degradation and subsequent nuclear translocation of NF-κB p65 in ECs. In the animal study, resveratrol supplementation in diet significantly diminished TNF-α-induced increases in circulating levels of adhesion molecules and cytokines, monocyte adhesion to mouse aortic ECs, F4/80-positive macrophages and VCAM-1 expression in mice aortas and restored the disruption in aortic elastin fiber caused by TNF-α treatment. The animal study also confirmed that resveratrol blocks the activation of NF-κB In Vivo. In conclusion, resveratrol at physiologically achievable concentrations displayed protective effects against TNF-α-induced vascular endothelial inflammation in vitro and In Vivo. The ability of resveratrol in reducing inflammation may be associated with its role as a down-regulator of the NF-κB pathway.
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影响因子：
5.6
作者：
Arida A;Protogerou AD;Kitas GD;Sfikakis PP
通讯作者：
Sfikakis PP
白藜芦醇通过激活乳腺癌 1 型易感蛋白下调 miR-155，从而改善心脏肥大
影响因子：
5.4
作者：
Fan Y;Liu L;Fang K;Huang T;Wan L;Liu Y;Zhang S;Yan D;Li G;Gao Y;Lv Y;Chen Y;Tu Y
通讯作者：
Tu Y
影响因子：
37.8
作者：
Bonow, RO;Smaha, LA;Lenfant, C
通讯作者：
Lenfant, C
影响因子：
3.4
作者：
Cong, Xiaoqiang;Li, Ying;Liu, Ya
通讯作者：
Liu, Ya
DOI：
10.1016/j.jnutbio.2014.11.008
发表时间：
2015-03
期刊：
The Journal of nutritional biochemistry
影响因子：
--
作者：
Jia Z;Nallasamy P;Liu D;Shah H;Li JZ;Chitrakar R;Si H;McCormick J;Zhu H;Zhen W;Li Y
通讯作者：
Li Y