Upconversion nanoparticles: a versatile solution to multiscale biological imaging.

Upconversion nanoparticles: a versatile solution to multiscale biological imaging.
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DOI:
10.1021/bc5003967
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发表时间:
2015-02-18
影响因子:
4.7
通讯作者:
Han, Gang
Han, Gang
中科院分区:
化学2区
文献类型:
--
作者:
Wu, Xiang;Chen, Guanying;Shen, Jie;Li, Zhanjun;Zhang, Yuanwei;Han, Gang

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镧系元素掺杂的光子上转换纳米材料正在成为一类新的成像造影剂,在生物医学成像领域提供了许多前所未有的可能性。由于它们能够将长波长近红外激发辐射转换为较短波长发射,这些纳米材料能够产生低成像背景、大反斯托克斯位移以及光的高光学穿透深度的资产,用于深层组织光学成像或光激活药物释放和治疗。本文综述了与传统荧光探针相关的一些问题,并讨论了上转换纳米颗粒(UCNPs)作为多尺度生物成像应用解决方案的最新进展。
Lanthanide-doped photon upconverting nanomaterials are emerging as a new class of imaging contrast agents, providing numerous unprecedented possibilities in the realm of biomedical imaging. Because of their ability to convert long-wavelength near-infrared excitation radiation into shorter-wavelength emissions, these nanomaterials are able to produce assets of low imaging background, large anti-Stokes shift, as well as high optical penetration depth of light for deep tissue optical imaging or light-activated drug release and therapy. The aim of this review is to line up some issues associated with conventional fluorescent probes, and to address the recent advances of upconverting nanoparticles (UCNPs) as a solution to multiscale biological imaging applications.
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