Functional overlaps between XLF and the ATM-dependent DNA double strand break response.
Functional overlaps between XLF and the ATM-dependent DNA double strand break response.
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DOI：
10.1016/j.dnarep.2014.01.010
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发表时间：
2014-04
期刊：
影响因子：
3.8
通讯作者：
Oksenych, Valentyn
中科院分区：
文献类型：
--
作者：
Kumar, Vipul;Alt, Frederick W.;Oksenych, Valentyn
发育中的B淋巴细胞和T淋巴细胞在V(D)J重组过程中产生程序性DNA双链断裂（DSBs），该过程组装编码抗体抗原结合可变区域的外显子。此外，成熟的B淋巴细胞在免疫球蛋白重链（IgH）类开关重组（CSR）过程中产生程序化的dsb，允许表达提供不同效应功能的不同抗体重链常数区。在V(D)J重组和CSR过程中，DSB中间体都通过依赖于atm的DSB响应（DSBR）途径被感知，这也有助于它们通过经典非同源末端连接（C-NHEJ）连接。DSBR和C-NHEJ通路在DSB通过C-NHEJ修复的情况下相互作用的确切性质仍在研究中。最近的研究表明，XLF C-NHEJ因子与C-NHEJ中依赖于自动取款机的DSBR通路的几个成员具有功能冗余，突出了XLF和DSBR在V(D)J重组、CSR和C-NHEJ中的主要作用。在这篇综述中，我们讨论了目前对B淋巴细胞发育和激活过程中产生的dsb修复机制的了解，重点关注XLF和atm依赖的DSBR因子的潜在功能冗余作用。
Developing B and T lymphocytes generate programmed DNA Double Strand Breaks (DSBs) during the V(D)J recombination process that assembles exons that encode the antigen-binding variable regions of antibodies. In addition, mature B lymphocytes generate programmed DSBs during the Immunoglobulin Heavy chain (IgH) Class Switch Recombination (CSR) process that allows expression of different antibody heavy chain constant regions that provide different effector functions. During both V(D)J recombination and CSR, DSB intermediates are sensed by the ATM-dependent DSB response (DSBR) pathway, which also contributes to their joining via Classical Non-Homologous End-Joining (C-NHEJ). The precise nature of the interplay between the DSBR and C-NHEJ pathways in the context of DSB repair via C-NHEJ remains under investigation. Recent studies have shown that the XLF C-NHEJ factor has functional redundancy with several members of the ATM-dependent DSBR pathway in C-NHEJ, highlighting unappreciated major roles for both XLF as well as the DSBR in V(D)J recombination, CSR and C-NHEJ in general. In this review, we discuss current knowledge of the mechanisms that contribute to the repair of DSBs generated during B lymphocyte development and activation with a focus on potential functionally redundant roles of XLF and ATM-dependent DSBR factors.
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影响因子：
64.5
作者：
Alt FW;Zhang Y;Meng FL;Guo C;Schwer B
通讯作者：
Schwer B
影响因子：
56.9
作者：
Celeste, A;Petersen, S;Nussenzweig, A
通讯作者：
Nussenzweig, A
影响因子：
--
作者：
Bednarski JJ;Sleckman BP
通讯作者：
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影响因子：
16
作者：
Callen, Elsa;Jankovic, Mila;Wong, Nancy;Zha, Shan;Chen, Hua-Tang;Difilippantonio, Simone;Di Virgilio, Michela;Heidkamp, Gordon;Alt, Frederick W.;Nussenzweig, Andre;Nussenzweig, Michel
通讯作者：
Nussenzweig, Michel
DOI：
10.1073/pnas.0915067107
发表时间：
2010-02-16
影响因子：
11.1
作者：
Boboila, Cristian;Jankovic, Mila;Alt, Frederick W.
通讯作者：
Alt, Frederick W.