Recent advancements in single dose slow-release devices for prophylactic vaccines.
Recent advancements in single dose slow-release devices for prophylactic vaccines.
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DOI：
10.1002/wnan.1832
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发表时间：
2023-01
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单剂量缓释疫苗预示着疫苗管理的新时代。用于缓释疫苗递送的理想装置将是微创的和自我施用的，使得这些方法成为大规模疫苗接种计划的有吸引力的替代方案，特别是在大流行期间。在这篇综述文章中，我们讨论了这一领域的最新进展，特别是能够预防传染病的预防性疫苗。最近的研究发现，缓释疫苗能引起更好的免疫反应，而且通常不需要冷链运输和储存，从而大大降低了成本，简化了分销，提高了疗效。这一前景吸引了极大的关注，特别是当考虑到标准多剂量疫苗方案的患者依从性差时。单剂量缓释疫苗是下一代疫苗工具，可以克服目前疫苗接种计划的大多数缺点，并成为对抗未来大流行病的下一个平台技术。
Single dose slow-release vaccines herald a new era in vaccine administration. An ideal device for slow-release vaccine delivery would be minimally invasive and self-administered, making these approaches an attractive alternative for mass vaccination programs, particularly during the time of a pandemic. In this review article, we discuss the latest advances in this field, specifically for prophylactic vaccines able to prevent infectious diseases. Recent studies have found that slow-release vaccines elicit better immune responses and often do not require cold chain transportation and storage, thus drastically reducing the cost, streamlining distribution, and improving efficacy. This promise has attracted significant attention, especially when poor patient compliance of the standard multidose vaccine regimes is considered. Single dose slow-release vaccines are the next generation of vaccine tools that could overcome most of the shortcomings of present vaccination programs and be the next platform technology to combat future pandemics.
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