Route of hepatocyte delivery affects hepatocyte engraftment in the spleen.
Route of hepatocyte delivery affects hepatocyte engraftment in the spleen.
复制标题
肝细胞输送途径影响肝细胞在脾脏中的植入。
DOI：
10.1097/01.tp.0000081560.16039.67
复制
发表时间：
2003
期刊：
影响因子：
--
通讯作者：
Fox,IraJ
中科院分区：
文献类型：
--
作者：
Nagata,Hideo;Ito,Masahiro;Shirota,Chiyoe;Edge,Albert;McCowan,TimothyC;Fox,IraJ
In laboratory animals, intrasplenic hepatocyte transplantation corrects the physiologic abnormalities associated with decompensated liver disease. The clinical experience with hepatocyte transplantation for cirrhosis has been disappointing when compared with laboratory experience. The route of hepatocyte delivery may influence hepatocyte engraftment and function. Outbred pigs were recipients of allogeneic pig hepatocytes. Donor hepatocytes were isolated by collagenase perfusion and labeled using 5 (6)-carboxyfluorescein diacetate succinimidyl-ester (CMFSE). Cells were introduced into pig spleens by infusion through the splenic artery or by direct splenic puncture. Direct intrasplenic injection produced engraftment that was far superior to that obtained using splenic artery infusion. Splenic artery infusion produced a gastric erosion and large areas of splenic necrosis secondary to vascular occlusion with hepatocytes, whereas direct splenic injection was associated with clinically insignificant intraabdominal hemorrhage. The route of hepatocyte delivery may influence hepatocyte engraftment and explain the disparity in efficacy of hepatocyte transplantation between the laboratory and clinic.
通过堵塞针道提高脾门静脉造影的安全性。
DOI：
--
发表时间：
1978
期刊：
AJR. American journal of roentgenology
影响因子：
--
作者：
P. Probst;J. Rysavy;K. Amplatz*
通讯作者：
K. Amplatz*
DOI：
10.1093/jnci/68.5.771
发表时间：
1982-05
期刊：
Journal of the National Cancer Institute
影响因子：
--
作者：
S. Strom;R. Jirtle;R. S. Jones;D. Novicki;M. R. Rosenberg;A. Novotny;G. Irons;J. R. McLain;G. Michalopoulos
通讯作者：
S. Strom;R. Jirtle;R. S. Jones;D. Novicki;M. R. Rosenberg;A. Novotny;G. Irons;J. R. McLain;G. Michalopoulos
数字脾门造影。
DOI：
--
发表时间：
1985
期刊：
AJR. American journal of roentgenology
影响因子：
--
作者：
S. Braun;G. E. Newman;N. Dunnick
通讯作者：
N. Dunnick