The role of EGF-EGFR signalling pathway in hepatocellular carcinoma inflammatory microenvironment.
The role of EGF-EGFR signalling pathway in hepatocellular carcinoma inflammatory microenvironment.
复制标题
EGF-EGFR信号通路在肝癌炎症微环境中的作用
DOI：
10.1111/jcmm.12153
复制
发表时间：
2014-02
影响因子：
5.3
通讯作者：
Xia J
中科院分区：
文献类型：
--
作者：
Huang P;Xu X;Wang L;Zhu B;Wang X;Xia J
Epidermal growth factor (EGF) and their receptor (EGFR) play an important role in the development of cancer proliferation, and metastasis, although the mechanism remains unclear. The present study aimed at investigating the role of EGF-EGFR signalling pathway in the development of human hepatocellular carcinoma (HCC) inflammatory environment. Gene profiles of inflammatory cytokines from HCC were measured. Cell bio-behaviours of HCC with low or high metastasis were detected by the live cell monitoring system. Cell proliferation was measured by CCK8. The protein level of CXCL5 and CXCL8 was measured by ELISA. The phosphorylation of PI3K, ERK, MAPK was measured by western blot. EGF significantly induced cell proliferation in HepG2 cells, but not in HCCLM3 cells. EGF prompted the cell movement in both HepG2 and HCCLM3 and regulated the production of CXCL5 and CXCL8 from HCC, which were inhibited by EGFR inhibitor, Erk inhibitor (U0126), or PI3K inhibitors (BEZ-235 and SHBM1009). HCC proliferation, metastasis and production of inflammatory cytokines were regulated via EGF-EGFR signal pathways. CXCL5 could interact with CXCL8, possibly by CXCR2 or the cross-talk between CXCR2 and EGFR. EGF-EGFR signaling pathway can be the potential target of therapies for HCC.
登录
查看更多内容
影响因子：
7.5
作者：
Gantsev, S. K.;Umezawa, K.;Kzyrgalin, S. R.
通讯作者：
Kzyrgalin, S. R.
影响因子：
3.8
作者：
Masuda, Hiroko;Zhang, Dongwei;Bartholomeusz, Chandra;Doihara, Hiroyoshi;Hortobagyi, Gabriel N.;Ueno, Naoto T.
通讯作者：
Ueno, Naoto T.
影响因子：
8.4
作者：
Kawamura, Mikio;Toiyama, Yuji;Kusunoki, Masato
通讯作者：
Kusunoki, Masato
DOI：
10.1073/pnas.0704126104
发表时间：
2007-10-23
影响因子：
11.1
作者：
Natarajan, Anuradha;Wagner, Bettina;Sibilia, Maria
通讯作者：
Sibilia, Maria
ERB-B受体家族在肝细胞癌中的表达和临床意义。
影响因子：
8.8
作者：
Ito, Y;Takeda, T;Sakon, M;Tsujimoto, M;Higashiyama, S;Noda, K;Miyoshi, E;Monden, M;Matsuura, N
通讯作者：
Matsuura, N