Risk factors and predictors of coronary arterial lesions in Japanese hypertensive patients.
Risk factors and predictors of coronary arterial lesions in Japanese hypertensive patients.
复制标题
日本高血压患者冠状动脉病变的危险因素和预测因素。
作者：
J. Kato;A. Aihara;M. Kikuya;M. Matsubara;M. Ohta;T. Ohkubo;I. Tsuji;H. Sekino;T. Meguro;Y. Imai
冠状动脉疾病的发病率最近在日本有所增加。这是由于从传统生活方式向更西化的生活方式的转变。因此，在本研究中，我们研究了日本原发性高血压患者冠状动脉病变的危险因素和预测因素。对109例原发性高血压患者（57例男性和52例女性; 66 ± 8.0岁）进行冠状动脉造影，这些患者均患有心绞痛或非典型胸痛，这些患者是从日本仙台市一家高血压诊所的485例连续高血压患者中选出的。冠状动脉狭窄大于50%被定义为显著的，并用作多元回归分析的因变量。危险因素被定义为被证实与冠状动脉病变有因果关系的因素，而动脉粥样硬化并发症和高血压靶器官损害被定义为预测因子。以这些参数为自变量进行多元Logistic回归分析。109例患者中，25例冠状动脉狭窄大于50%。抽烟的习惯（比值比（OR）：4.48; 95%置信区间（CI）：1.13-17.82; p<0.05），高胆固醇血症（OR：5.34; 95%CI：1.52-18.73; p<0.05），24小时舒张压（OR：2.33; 95%CI：1.06-5.16; p<0.05）是显著的危险因素，而颈动脉内膜中层厚度（OR：5.85，95% CI：1.48-23.2; p<0.05）是冠状动脉病变的显著预测因子。当两个主要的危险因素（吸烟习惯，高胆固醇血症，或葡萄糖耐量受损，包括糖尿病）聚集在一起，除了高血压，冠状动脉病变的风险增加了6.7至10.1倍。这些发现表明，在高加索人中建立的主要风险因素，即，吸烟习惯、高胆固醇血症和血压水平也是日本原发性高血压患者冠状动脉病变的危险因素。两种或两种以上危险因素的存在协同增加了高血压患者冠状动脉病变的风险。
The morbidity rate of coronary artery disease has recently increased in Japan. This is attributable to changes from traditional to more westernized lifestyles. In this study, we therefore examined the risk factors and predictors of coronary arterial lesions in Japanese patients with essential hypertension. Coronary angiography was performed in 109 consecutive essential hypertension patients (57 men and 52 women; 66 +/- 8.0 years of age) with either angina pectoris or atypical chest pain, who were chosen from 485 consecutive hypertensive patients in a hypertension clinic in Sendai, Japan. Coronary arterial stenosis of greater than 50% was defined as significant and used as a dependent variable for the multiple regression analysis. Risk factors were defined as factors confirmed to have a causal relationship with coronary arterial lesions, whereas arteriosclerotic complications and hypertensive target organ damage were defined as predictors. Multiple logistic regression analysis was performed using these parameters as independent variables. Of 109 patients, 25 had a coronary arterial stenosis greater than 50%. A smoking habit (odds ratio (OR): 4.48; 95% confidence interval (CI): 1.13-17.82; p<0.05), hypercholesterolemia (OR: 5.34; 95% CI: 1.52-18.73; p<0.05), and 24-h diastolic blood pressure (OR: 2.33; 95% CI: 1.06-5.16; p<0.05) were significant risk factors, whereas carotid intima-media thickness (OR: 5.85; 95% CI: 1.48-23.2; p<0.05) was a significant predictor of coronary arterial lesion. When two of the major risk factors (a smoking habit, hypercholesterolemia, or impaired glucose tolerance including diabetes mellitus) were clustered in addition to the hypertension, the risk of coronary arterial lesions increased by 6.7 to 10.1 times. These findings indicate that the major risk factors established in Caucasians, i.e., a smoking habit, hypercholesterolemia and blood pressure level, are also risk factors for coronary arterial lesions in Japanese with essential hypertension. The presence of two or more risk factors increases the risk of coronary arterial lesions synergistically in the presence of hypertension.
危险因素与动脉造影定义的冠状动脉疾病的关联：合适的对照组是什么？
影响因子：
5
作者：
Fried,LP;Pearson,TA
通讯作者：
Pearson,TA
影响因子：
8.3
作者：
OLeary, DH;Polak, JF;Furberg, CD
通讯作者：
Furberg, CD