Ion channel activities in neural stem cells of the neuroepithelium.
Ion channel activities in neural stem cells of the neuroepithelium.
复制标题
DOI：
10.1155/2012/247670
复制
发表时间：
2012
影响因子：
4.3
通讯作者：
Yamashita M
中科院分区：
文献类型：
--
作者：
Yamashita M
在中枢神经系统的胚胎发育过程中，神经上皮细胞充当神经干细胞。在细胞周期中，它们沿其顶基轴进行核间运动沿着。神经上皮细胞在S期响应G蛋白偶联受体激活而显示核质[Ca 2 +]的强劲增加，在此期间细胞核位于神经上皮细胞的基底区。这种反应是由细胞内Ca 2+库释放的Ca 2+引起的，细胞内Ca 2+库由内质网和核膜组成。Ca 2+释放导致从细胞外空间的Ca 2+进入的激活，这被称为容量性或储存操作的Ca 2+进入。Ca ~（2+）的这些运动对S期DNA合成是必不可少的。自发的Ca 2+振荡也在细胞间同步发生。这种同步化是由由于Ca 2+释放和K+离子的反向运动引起的核膜膜电位的电压波动介导的;电压波动诱导交流电流（AC），其通过电容性电耦合传输到相邻细胞。通过降低输入电阻，通过间隙连接耦合来稳定跨质膜的膜电位。因此，储存的Ca 2+离子是维持神经上皮细胞细胞活性的关键因素。
During the embryonic development of the central nervous system, neuroepithelial cells act as neural stem cells. They undergo interkinetic nuclear movements along their apico-basal axis during the cell cycle. The neuroepithelial cell shows robust increases in the nucleoplasmic [Ca2+] in response to G protein-coupled receptor activation in S-phase, during which the nucleus is located in the basal region of the neuroepithelial cell. This response is caused by Ca2+ release from intracellular Ca2+ stores, which are comprised of the endoplasmic reticulum and the nuclear envelope. The Ca2+ release leads to the activation of Ca2+ entry from the extracellular space, which is called capacitative, or store-operated Ca2+ entry. These movements of Ca2+ are essential for DNA synthesis during S-phase. Spontaneous Ca2+ oscillations also occur synchronously across the cells. This synchronization is mediated by voltage fluctuations in the membrane potential of the nuclear envelope due to Ca2+ release and the counter movement of K+ ions; the voltage fluctuation induces alternating current (AC), which is transmitted via capacitative electrical coupling to the neighboring cells. The membrane potential across the plasma membrane is stabilized through gap junction coupling by lowering the input resistance. Thus, stored Ca2+ ions are a key player in the maintenance of the cellular activity of neuroepithelial cells.
登录
查看更多内容
影响因子：
5.3
作者：
Smyth JT;Hwang SY;Tomita T;DeHaven WI;Mercer JC;Putney JW
通讯作者：
Putney JW
DOI：
10.1016/s0736-5748(96)00074-3
发表时间：
1996-10-01
影响因子：
1.8
作者：
Sakaki, Y;Fukuda, Y;Yamashita, M
通讯作者：
Yamashita, M
影响因子：
5.5
作者：
Sugioka, M;Fukuda, Y;Yamashita, M
通讯作者：
Yamashita, M
影响因子：
2.5
作者：
Sauer, FC
通讯作者：
Sauer, FC
影响因子：
64.8
作者：
Andang, Michael;Hjerling-Leffler, Jens;Ernfors, Patrik
通讯作者：
Ernfors, Patrik