Endotoxin elicits normal tryptophan and indolamine responses but impaired catecholamine and pituitary-adrenal responses in endotoxin-resistant mice.
Endotoxin elicits normal tryptophan and indolamine responses but impaired catecholamine and pituitary-adrenal responses in endotoxin-resistant mice.
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内毒素会引起正常的色氨酸和吲哚胺反应，但会损害内毒素抗性小鼠的儿茶酚胺和垂体肾上腺反应。
DOI：
10.1016/0024-3205(94)00621-0
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发表时间：
1994
期刊：
影响因子：
6.1
通讯作者：
Chuluyan,HE
中科院分区：
文献类型：
--
作者：
Dunn,AJ;Chuluyan,HE
研究了内毒素抵抗小鼠对内毒素、新城疫病毒和白介素1的神经化学和内分泌反应。长期以来，脂多糖一直被认为是下丘脑-垂体-肾上腺皮质轴的有效刺激物，但它也会增加大脑中去甲肾上腺素(NE)和5-羟色胺(5-HT)的分解代谢产物以及游离酪氨酸的浓度。内毒素抗性C3H/HEJ品系小鼠的血浆ACTH和皮质酮(CS)对脂多糖的反应明显低于对照C3H/HEN品系。C3H/HEN组小鼠脑内NE分解代谢产物MHPG和多巴胺分解代谢产物DOPAC均升高，而C3H/HEJ小鼠则无此变化。然而，两个菌株的吲哚胺能反应、色氨酸和5-羟色胺分解代谢产物5-HIAA的增加是相似的。新城疫病毒引起的反应与内毒素非常相似，色氨酸和5-HIAA增加，但儿茶酚胺、ACTH和CS的反应减弱。已知IL-1在注射内毒素(可能还有新城疫病毒)后合成和分泌，并产生类似的内分泌和神经化学效应。在C3H/HeJ小鼠中，IL-1可引起血浆ACTH和CS以及脑内MHPG、5-HIAA和色氨酸的正常升高。因此，C3H/HeJ小鼠的缺陷并不反映儿茶酚胺和HPA轴对免疫系统做出反应的能力的变化，但可能发生在由内毒素和新城疫病毒启动的反应序列的早期。这些结果还表明，内毒素通过相似或相关的机制激活脑儿茶酚胺和HPA轴，而吲哚胺能反应显然是通过不同的机制发生的。
The neurochemical and endocrine response to endotoxin (LPS), Newcastle disease virus (NDV) and interleukin-1 (IL-1) administration were studied in endotoxin-resistant mice. LPS has long been known to be a potent stimulator of the hypothalamo-pituitary-adrenocortical axis, but it also increases brain concentrations of the catabolites of norepinephrine (NE) and serotonin (5-HT), as well as free trytophan. Mice of the endotoxin-resistant C3H/HeJ strain showed markedly reduced responses in plasma ACTH and corticosterone (CS) to intraperitoneal LPS compared to the control C3H/HeN strain. C3H/HeN mice displayed increases in the cerebral NE catabolite, MHPG, and the dopamine catabolite, DOPAC, but no such increases occured in C3H/HeJ mice. However, the indolaminergic responses, increases of tryptophan and the serotonin catabolite, 5-HIAA, were similar in the two strains. NDV administration induced responses very similar to those of LPS; increases in tryptophan and 5-HIAA, but impaired responses in catecholamines, ACTH and CS. IL-1 is known to be synthesized and secreted following LPS (and probably NDV) administration, and produces similar endocrine and neurochemical effects. In C3H/HeJ mice, IL-1 elicited normal increases in plasma ACTH and CS, as well as cerebral MHPG, 5-HIAA and tryptophan. Thus the deficits in C3H/HeJ mice do not reflect alterations in the ability of catecholamines and the HPA axis to respond to the immune system, but probably occur early in the sequence of reactions initiated by LPS and NDV. These results also suggest that LPS activites cerebral catecholamines and the HPA axis by similar or related mechanisms, whereas the indolaminergic responses apparently occur via a different mechanism.
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影响因子：
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