Microbes, the gut and ankylosing spondylitis.

Microbes, the gut and ankylosing spondylitis.
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微生物,肠道和强直性脊柱炎。

DOI:
10.1186/ar4228
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发表时间:
2013
影响因子:
4.9
通讯作者:
Brown MA
Brown MA
中科院分区:
医学2区
文献类型:
--
作者:
Costello ME;Elewaut D;Kenna TJ;Brown MA

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越来越清楚的是,宿主和微生物群之间的相互作用深刻地影响着健康。我们体内和身上的细菌比我们自己的细胞总数多10倍,人类的肠道含有大约100万亿个细菌。使用经典微生物学技术对微生物群落进行讯问提供了对这些群落非常有限的看法,使我们只能看到我们可以孤立生长的东西。然而,测序技术的最新进展极大地促进了对微生物组在人类健康和疾病中的作用的系统和全面的研究。全面了解我们的微生物组将加强对疾病发病机制的理解,这反过来可能导致对包括自身免疫在内的许多疾病进行合理的靶向治疗。
It is increasingly clear that the interaction between host and microbiome profoundly affects health. There are 10 times more bacteria in and on our bodies than the total of our own cells, and the human intestine contains approximately 100 trillion bacteria. Interrogation of microbial communities by using classic microbiology techniques offers a very restricted view of these communities, allowing us to see only what we can grow in isolation. However, recent advances in sequencing technologies have greatly facilitated systematic and comprehensive studies of the role of the microbiome in human health and disease. Comprehensive understanding of our microbiome will enhance understanding of disease pathogenesis, which in turn may lead to rationally targeted therapy for a number of conditions, including autoimmunity.
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影响因子: 64.8
作者:
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