When Rhythm Changes Cause the Blues: New-Onset Atrial Fibrillation during Sepsis.
When Rhythm Changes Cause the Blues: New-Onset Atrial Fibrillation during Sepsis.
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当节律变化导致忧郁时：败血症期间新发的心房颤动。
DOI：
10.1164/rccm.201608-1617ed
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发表时间：
2017
影响因子：
24.7
通讯作者：
McManus,David
中科院分区：
文献类型：
--
作者：
Walkey,AllanJ;McManus,David
During the past decade, atrial fibrillation (AF) has become increasingly recognized as a complication of sepsis (1–4). Multiple physiological changes during sepsis (1, 5, 6) interact to generate an atrial substrate vulnerable to AF, resulting in more than a sixfold (2) greater risk for developing AF during sepsis compared with other reasons for hospitalization. Only postoperative patients have similarly high risks for development of new-onset AF (7). However, evidence-based guidelines support interventions to prevent postoperative AF (8), whereas few approaches have been developed to guide the prevention or management of AF in the context of sepsis.If development of AF results in worse sepsis outcomes, then prevention of AF during sepsis represents a logical clinical goal. Administrative claims data suggest that patients who develop AF during sepsis generally do not have a high burden of cardiovascular comorbidities associated with risk of “conventional” AF (9), but nearly one-half of patients with new-onset AF during sepsis experience recurrent AF after hospital discharge (10). Thus, prevention of AF during sepsis may avoid entrainment of the arrhythmogenic pathways that lead to chronic AF and its complications in patients who otherwise might have been at low risk for development of AF. Further evidence supporting a role for AF in contributing to poor sepsis outcomes generally comes from studies that used administrative claims data (2), but characterization of the clinical course of sepsis using claims data is limited. Whether AF is merely an epiphenomenon of acute sepsis severity without a role for modifying outcomes, or can directly worsen sepsis, has thus far been unclear (11).
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DOI：
10.1164/rccm.201603-0618oc
发表时间：
2017-01-15
影响因子：
24.7
作者：
Klouwenberg, Peter M. C. Klein;Frencken, Jos F.;Cremer, Olaf L.
通讯作者：
Cremer, Olaf L.
影响因子：
3.7
作者：
Christian, Sangita-Ann;Schorr, Christa;Gerber, David R.
通讯作者：
Gerber, David R.
影响因子：
120.7
作者：
Walkey, Allan J.;Wiener, Renda Soylemez;Ghobrial, Joanna M.;Curtis, Lesley H.;Benjamin, Emelia J.
通讯作者：
Benjamin, Emelia J.
影响因子：
4.8
作者：
Walkey, Allan J.;Greiner, Melissa A.;Heckbert, Susan R.;Jensen, Paul N.;Piccini, Jonathan P.;Sinner, Moritz F.;Curtis, Lesley H.;Benjamin, Emelia J.
通讯作者：
Benjamin, Emelia J.
脓毒症中新发心房颤动：很常见，但又很不同。
影响因子：
8.8
作者：
C. Guenancia;G. Laurent;R. Bruyère;J. Quenot
通讯作者：
J. Quenot