The functional and anatomical dissection of somatosensory subpopulations using mouse genetics.
The functional and anatomical dissection of somatosensory subpopulations using mouse genetics.
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DOI：
10.3389/fnana.2014.00021
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发表时间：
2014
影响因子：
2.9
通讯作者：
Chesler AT
中科院分区：
文献类型：
--
作者：
Le Pichon CE;Chesler AT
体感这个词来自于希腊语中表示身体（soma）的词与表示知觉（感觉）的词的结合。体感神经元构成哺乳动物最大的感觉系统，其神经末梢遍布皮肤、内脏、肌肉和骨骼。它们的细胞体位于邻近背脊髓（背根神经节）和颅骨底部（三叉神经节）的神经节链中。虽然神经元细胞体混合在神经节内，但体感系统实际上由许多子系统组成，每个子系统专门检测不同的刺激，例如温度和触摸。历史上，体感神经元使用多种解剖学和生理学参数进行分类，例如细胞体的大小、髓鞘化程度、标记物的组织学标记、神经末梢的特化、脊髓和脑干的投射模式、感受性调谐以及动作电位的传导速度。虽然有用，但出现的图片是异质性的，许多标记至少部分重叠。最近，通过利用分子技术的进步，研究人员已经确定了感觉神经元亚群中表达的特定离子通道和感觉受体。这些研究已被证明是无价的，因为它们允许对小部分神经元进行遗传分析，以进行进一步的分子解剖。从转基因小鼠产生的数据有利于一种模型，其中一组专用神经元负责选择性编码不同的模式。在这里，我们回顾了目前对小鼠不同感觉神经元亚型的了解，用于研究它们的标记，以及用于定义其解剖学预测和功能作用的神经发生策略。
The word somatosensation comes from joining the Greek word for body (soma) with a word for perception (sensation). Somatosensory neurons comprise the largest sensory system in mammals and have nerve endings coursing throughout the skin, viscera, muscle, and bone. Their cell bodies reside in a chain of ganglia adjacent to the dorsal spinal cord (the dorsal root ganglia) and at the base of the skull (the trigeminal ganglia). While the neuronal cell bodies are intermingled within the ganglia, the somatosensory system is in reality composed of numerous sub-systems, each specialized to detect distinct stimuli, such as temperature and touch. Historically, somatosensory neurons have been classified using a diverse host of anatomical and physiological parameters, such as the size of the cell body, degree of myelination, histological labeling with markers, specialization of the nerve endings, projection patterns in the spinal cord and brainstem, receptive tuning, and conduction velocity of their action potentials. While useful, the picture that emerged was one of heterogeneity, with many markers at least partially overlapping. More recently, by capitalizing on advances in molecular techniques, researchers have identified specific ion channels and sensory receptors expressed in subsets of sensory neurons. These studies have proved invaluable as they allow genetic access to small subsets of neurons for further molecular dissection. Data being generated from transgenic mice favor a model whereby an array of dedicated neurons is responsible for selectively encoding different modalities. Here we review the current knowledge of the different sensory neuron subtypes in the mouse, the markers used to study them, and the neurogenetic strategies used to define their anatomical projections and functional roles.
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DOI：
10.1523/jneurosci.6451-10.2011
发表时间：
2011-03-30
期刊：
The Journal of neuroscience : the official journal of the Society for Neuroscience
影响因子：
--
作者：
Cavanaugh DJ;Chesler AT;Jackson AC;Sigal YM;Yamanaka H;Grant R;O'Donnell D;Nicoll RA;Shah NM;Julius D;Basbaum AI
通讯作者：
Basbaum AI
影响因子：
64.8
作者：
Chuang, HH;Prescott, ED;Julius, D
通讯作者：
Julius, D
影响因子：
25
作者：
Chavez, Andres E.;Chiu, Chiayu Q.;Castillo, Pablo E.
通讯作者：
Castillo, Pablo E.
DOI：
10.1523/jneurosci.1299-11.2011
发表时间：
2011-07-13
期刊：
The Journal of neuroscience : the official journal of the Society for Neuroscience
影响因子：
--
作者：
Cavanaugh DJ;Chesler AT;Bráz JM;Shah NM;Julius D;Basbaum AI
通讯作者：
Basbaum AI
影响因子：
16.2
作者：
Colburn, Raymond W.;Lubin, Mary Lou;Qin, Ning
通讯作者：
Qin, Ning