Serum angiogenin as a potential biomarker for early detection of colorectal adenomas and colorectal cancer
Serum angiogenin as a potential biomarker for early detection of colorectal adenomas and colorectal cancer
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血清血管生成素作为结直肠腺瘤和结直肠癌早期检测的潜在生物标志物
DOI：
10.1097/cad.0000000000001047
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发表时间：
2021-03
影响因子：
2.3
通讯作者：
Xu Zhengping
中科院分区：
文献类型：
--
作者：
Yu Dongdong;Sun Jun;Weng Yu;Luo Liang;Sheng Jinghao;Xu Zhengping
虽然结直肠癌（CRC）是癌症死亡率最常见的原因之一，但早期检测可显著提高生存率。为探讨血清血管生成素（angiogenin，ANG）作为结直肠肿瘤早期诊断指标的可行性，我们收集了781例受试者的血清样本，包括369例结直肠癌患者，133例结直肠腺瘤患者和279例健康对照者。采用ELISA法检测血清ANG水平，绘制受试者工作特征曲线（ROC）计算ANG诊断的准确性，并与癌胚抗原（CEA）和糖链抗原19-9（CA 19 -9）检测结果进行比较。分析了血清ANG水平与结直肠癌TNM分期的关系。结果表明，大肠腺瘤和大肠癌患者血清ANG水平明显升高（P < 0.01）。ANG区分CRC患者和健康对照的ROC曲线下面积（AUC）为0.740 [95%可信区间（CI）：0.705-0.744]，与CEA相当（0.770; 95%CI：0.735-0.802; P = 0.26），但显著高于CA 19 -9（0.636; 95% CI：0.598-0.674，P < 0.01），其敏感性（67.75%）明显高于CEA（36.86%）和CA 19 -9（12.20%）。我们观察到不同TNM分期的CRC之间ANG血清水平无显著差异。ANG对结直肠腺瘤患者和健康对照者的敏感性和特异性分别为66.20%和64.90%。ANG有可能作为早期发现结直肠肿瘤的血清生物标志物。
Although colorectal cancer (CRC) is one of the most common causes of cancer mortality, early-stage detection dramatically improves survival rate. To explore the feasibility of serum angiogenin (ANG) as a biomarker for early detection of colorectal neoplasia, we collected serum samples from 781 participants, including 369 patients with CRC, 133 with colorectal adenoma and 279 healthy controls. We examined the levels of serum ANG by ELISA, calculated the diagnostic accuracy of ANG by plotted receiver operating characteristic curves (ROCs), and compared it with those obtained by carcinoembryonic antigen (CEA) and carbohydrate antigen 19-9 (CA19-9). We also analyzed the relationship between serum ANG level and TNM stage in CRC patients. The results showed that ANG serum levels were significantly elevated in patients with colorectal adenomas and CRC (P < 0.01). The area under the ROC curve (AUC) for ANG in distinguishing CRC patients from healthy controls was 0.740 [95% confidence interval (CI): 0.705–0.744], comparable to that of CEA (0.770; 95% CI: 0.735–0.802; P = 0.26) but significantly higher than that of CA19-9 (0.636; 95% CI: 0.598–0.674, P < 0.01), with much higher sensitivity (67.75%) than CEA (36.86%) or CA19-9 (12.20%). We observed no significant differences in ANG serum levels among CRCs at different TNM stages. Furthermore, sensitivity and specificity of ANG for distinguishing colorectal adenomas patients from healthy controls were 66.20% and 64.90%, respectively. ANG has the potential to serve as a serum biomarker for early detection of colorectal neoplasia.
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影响因子：
--
作者：
Gonzalez-Pons M;Cruz-Correa M
通讯作者：
Cruz-Correa M
影响因子：
2.4
作者：
M. Goldstein;E. Mitchell
通讯作者：
M. Goldstein;E. Mitchell
影响因子：
--
作者：
Kevin M. Rank;A. Shaukat
通讯作者：
Kevin M. Rank;A. Shaukat
影响因子：
2.9
作者：
FETT, JW;STRYDOM, DJ;VALLEE, BL
通讯作者：
VALLEE, BL
影响因子：
7.7
作者：
Overholt, Bergein F.;Wheeler, Donald J.;Fritsche, Herbert A.
通讯作者：
Fritsche, Herbert A.