Colorectal Cancer Biomarkers: Where Are We Now?
Colorectal Cancer Biomarkers: Where Are We Now?
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DOI：
10.1155/2015/149014
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发表时间：
2015
影响因子：
--
通讯作者：
Cruz-Correa M
中科院分区：
文献类型：
--
作者：
Gonzalez-Pons M;Cruz-Correa M
结直肠癌是西方世界癌症相关死亡的主要原因之一。患者的生存率高度依赖于诊断时的肿瘤分期。对化疗敏感性的降低仍然是有效治疗晚期疾病的主要障碍。由于结直肠癌在发展到晚期之前大多数是无症状的，因此实施旨在早期发现的筛查计划对于降低发病率和死亡率至关重要。目前的筛查和诊断方法从半侵入性程序（如结肠镜检查）到基于粪便的非侵入性测试。症状的缺乏，目前使用的方法的半侵入性性质，以及粪便血液测试的次优准确性的组合导致相当数量的个体中晚期结直肠癌诊断。导致结直肠癌发生的基因表达的改变反映在核酸和蛋白质的失调水平上，这可用于开发新的微创分子生物标志物。这篇综述的目的是讨论商业上可用的结直肠癌分子诊断方法，以及突出一些新的候选预测和预后的肿瘤，粪便和血液样本的分子标志物。
Colorectal cancer is one of the major causes of cancer-related death in the Western world. Patient survival is highly dependent on the tumor stage at the time of diagnosis. Reduced sensitivity to chemotherapy is still a major obstacle in effective treatment of advanced disease. Due to the fact that colorectal cancer is mostly asymptomatic until it progresses to advanced stages, the implementation of screening programs aimed at early detection is essential to reduce incidence and mortality rates. Current screening and diagnostic methods range from semi-invasive procedures such as colonoscopy to noninvasive stool-based tests. The combination of the absence of symptoms, the semi-invasive nature of currently used methods, and the suboptimal accuracy of fecal blood tests results in colorectal cancer diagnosis at advanced stages in a significant number of individuals. Alterations in gene expression leading to colorectal carcinogenesis are reflected in dysregulated levels of nucleic acids and proteins, which can be used for the development of novel, minimally invasive molecular biomarkers. The purpose of this review is to discuss the commercially available colorectal cancer molecular diagnostic methods as well as to highlight some of the new candidate predictive and prognostic molecular markers for tumor, stool, and blood samples.
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DOI：
10.3109/00365519709055283
发表时间：
1997-11-01
影响因子：
2.1
作者：
DeKok, JB;VanSolinge, WW;Swinkels, DW
通讯作者：
Swinkels, DW
影响因子：
3.6
作者：
Bachman, KE;Argani, P;Park, BH
通讯作者：
Park, BH
影响因子：
50.5
作者：
De Roock, W.;Piessevaux, H.;Tejpar, S.
通讯作者：
Tejpar, S.
影响因子：
45.3
作者：
Bertagnolli, Monica M.;Niedzwiecki, Donna;Redston, Mark
通讯作者：
Redston, Mark
血清中 microRNA 的表征：一类用于诊断癌症和其他疾病的新型生物标志物
影响因子：
44.1
作者：
Chen, Xi;Ba, Yi;Zhang, Chen-Yu
通讯作者：
Zhang, Chen-Yu