Complicated Muscle-Bone Interactions in Children with Cerebral Palsy.
Complicated Muscle-Bone Interactions in Children with Cerebral Palsy.
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DOI：
10.1007/s11914-020-00561-y
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发表时间：
2020-02
影响因子：
4.3
通讯作者：
Zhang C
中科院分区：
文献类型：
--
作者：
Modlesky CM;Zhang C
本综述的目的是强调脑瘫（CP）儿童的肌肉和骨骼缺陷，讨论脑瘫人群的肌肉和骨骼关系，并确定可能刺激其骨骼发育改善的肌肉干预策略。最新的研究表明，患有CP的儿童的肌肉和骨骼都严重发育不全和虚弱，即使是患有轻度疾病的流动儿童也是如此。肌肉体积小、运动能力差以及缺乏体育活动可能是导致CP儿童骨骼发育不良的主要原因。然而，肌肉与骨骼的关系可能因其他因素而变得复杂，如肌肉中脂肪和胶原蛋白的高度浸润、非典型肌肉激活和肌肉痉挛。以肌肉为基础的干预，如阻力训练、振动和营养补充，有可能改善CP儿童的骨骼发育，特别是如果他们在青春期前开始。需要进行研究，以确定对CP儿童骨骼发育影响最大的肌肉相关因素。确定利用肌肉和骨骼关系的治疗策略，同时改善平衡、协调和体育活动参与，是增加骨骼强度和减少CP儿童骨折的重要一步。
The goal of this review is to highlight the deficits in muscle and bone in children with cerebral palsy (CP), discuss the muscle-bone relationship in the CP population and identify muscle-based intervention strategies that may stimulate an improvement in their bone development. The latest research suggests that muscle and bone are both severely underdeveloped and weak in children with CP, even in ambulatory children with mild forms of the disorder. The small and low-performing muscles and limited participation in physical activity are likely the major contributors to the poor bone development in children with CP. However, the muscle-bone relationship may be complicated by other factors, such as a high degree of fat and collagen infiltration of muscle, atypical muscle activation, and muscle spasticity. Muscle-based interventions, such as resistance training, vibration and nutritional supplementation, have the potential to improve bone development in children with CP, especially if they are initiated before puberty. Studies are needed to identify the muscle-related factors with the greatest influence on bone development in children with CP. Identifying treatment strategies that capitalize on the relationship between muscle and bone, while also improving balance, coordination and physical activity participation, is an important step toward increasing bone strength and minimizing fractures in children with CP.
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DOI：
10.1002/jbmr.2689
发表时间：
2016-02
期刊：
Journal of bone and mineral research : the official journal of the American Society for Bone and Mineral Research
影响因子：
--
作者：
Ashpole NM;Herron JC;Mitschelen MC;Farley JA;Logan S;Yan H;Ungvari Z;Hodges EL;Csiszar A;Ikeno Y;Humphrey MB;Sonntag WE
通讯作者：
Sonntag WE
影响因子：
6.2
作者：
Fuchs, RK;Bauer, JJ;Snow, CM
通讯作者：
Snow, CM
DOI：
10.1111/j.1469-8749.2003.tb00954.x
发表时间：
2003-08-01
影响因子：
3.8
作者：
Elder, GCB;Kirk, J;Leahey, L
通讯作者：
Leahey, L
影响因子：
4.1
作者：
Bajaj, Deepti;Allerton, Brianne M.;Modlesky, Christopher M.
通讯作者：
Modlesky, Christopher M.
影响因子：
--
作者：
FROST, HM
通讯作者：
FROST, HM