Therapeutic opportunities for targeting the ubiquitous cell surface receptor CD47.
Therapeutic opportunities for targeting the ubiquitous cell surface receptor CD47.
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DOI：
10.1517/14728222.2013.733699
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发表时间：
2013-01
影响因子：
5.8
通讯作者：
Roberts DD
中科院分区：
文献类型：
--
作者：
Soto-Pantoja DR;Stein EV;Rogers NM;Sharifi-Sanjani M;Isenberg JS;Roberts DD
CD 47是一种广泛表达的细胞表面受体，在先天免疫系统识别自身时作为SIRPα的反受体。独立地，CD 47也作为调节细胞对应激反应的重要信号受体发挥作用。本文综述了CD 47在心血管和免疫系统中的表达、分子相互作用和病理生理功能。CD 47首先被确定为一种潜在的肿瘤标志物，我们研究了最近的证据，表明其失调有助于癌症进展和逃避抗肿瘤免疫。我们进一步讨论了增强或抑制CD 47信号传导的治疗策略，以及这些药物在缺血和缺血/再灌注损伤、器官移植、肺动脉高压、放射防护和癌症的临床前模型中的应用。正在进行的研究揭示了CD 47在细胞外微环境中传递信号的核心作用，这些信号在暴露于各种类型的应激时限制细胞和组织的存活。基于这一关键功能，靶向CD 47或其配体血小板反应蛋白-1和SIRPα的治疗剂可能具有广泛的应用，包括重建手术、组织和生物相容性表面的工程化、血管疾病、糖尿病、器官移植、辐射损伤、炎性疾病和癌症。
CD47 is a ubiquitously expressed cell surface receptor that serves as a counter-receptor for SIRPα in recognition of self by the innate immune system. Independently, CD47 also functions as an important signaling receptor for regulating cell responses to stress. We review the expression, molecular interactions, and pathophysiological functions of CD47 in the cardiovascular and immune systems. CD47 was first identified as a potential tumor marker, and we examine recent evidence that its dysregulation contributes to cancer progression and evasion of anti-tumor immunity. We further discuss therapeutic strategies for enhancing or inhibiting CD47 signaling and applications of such agents in preclinical models of ischemia and ischemia/reperfusion injuries, organ transplantation, pulmonary hypertension, radioprotection, and cancer. Ongoing studies are revealing a central role of CD47 for conveying signals from the extracellular microenvironment that limit cell and tissue survival upon exposure to various types of stress. Based on this key function, therapeutics targeting CD47 or its ligands thrombospondin-1 and SIRPα could have broad applications spanning reconstructive surgery, engineering of tissues and biocompatible surfaces, vascular diseases, diabetes, organ transplantation, radiation injuries, inflammatory diseases, and cancer.
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DOI：
10.1084/jem.194.4.541
发表时间：
2001-08-20
期刊：
The Journal of experimental medicine
影响因子：
--
作者：
Blazar BR;Lindberg FP;Ingulli E;Panoskaltsis-Mortari A;Oldenborg PA;Iizuka K;Yokoyama WM;Taylor PA
通讯作者：
Taylor PA
影响因子：
11.2
作者：
Chao MP;Alizadeh AA;Tang C;Jan M;Weissman-Tsukamoto R;Zhao F;Park CY;Weissman IL;Majeti R
通讯作者：
Majeti R
影响因子：
4.8
作者：
Frazier, WA;Gao, AG;Linder, ME
通讯作者：
Linder, ME
DOI：
10.1073/pnas.0906549106
发表时间：
2009-08-18
影响因子：
11.1
作者：
Chan, Keith Syson;Espinosa, Inigo;Weissman, Irving L.
通讯作者：
Weissman, Irving L.
与CD47功能化血接触表面的血小板和中性粒细胞的粘附和激活减少。
影响因子：
14
作者：
Finley, Matthew J.;Rauova, Lubica;Alferiev, Ivan S.;Weisel, John W.;Levy, Robert J.;Stachelek, Stanley J.
通讯作者：
Stachelek, Stanley J.