Structure of human cardiac thin filament in the calcium bound state
Structure of human cardiac thin filament in the calcium bound state
复制标题
钙结合态人心脏细丝的结构
DOI：
10.2210/pdb6kn8/pdb
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发表时间：
2020
影响因子：
16.6
通讯作者：
T. Fujii
中科院分区：
文献类型：
--
作者：
Yurika Yamada;K. Namba;T. Fujii
Contraction of striated muscles is driven by cyclic interactions of myosin head projecting from the thick filament with actin filament and is regulated by Ca2+ released from sarcoplasmic reticulum. Muscle thin filament consists of actin, tropomyosin and troponin, and Ca2+ binding to troponin triggers conformational changes of troponin and tropomyosin to allow actin-myosin interactions. However, the structural changes involved in this regulatory mechanism remain unknown. Here we report the structures of human cardiac muscle thin filament in the absence and presence of Ca2+ by electron cryomicroscopy. Molecular models in the two states built based on available crystal structures reveal the structures of a C-terminal region of troponin I and an N-terminal region of troponin T in complex with the head-to-tail junction of tropomyosin together with the troponin core on actin filament. Structural changes of the thin filament upon Ca2+ binding now reveal the mechanism of Ca2+ regulation of muscle contraction.
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影响因子：
64.8
作者：
von der Ecken, Julian;Mueller, Mirco;Lehman, William;Manstein, Dietmar J.;Penczek, Pawel A.;Raunser, Stefan
通讯作者：
Raunser, Stefan
影响因子：
64.8
作者：
von der Ecken, Julian;Heissler, Sarah M.;Raunser, Stefan
通讯作者：
Raunser, Stefan
放松状态下心肌细丝上肌钙蛋白的三维组织。
影响因子：
3.4
作者：
Yang,Shixin;Barbu-Tudoran,Lucian;Orzechowski,Marek;Craig,Roger;Trinick,John;White,Howard;Lehman,William
通讯作者：
Lehman,William
DOI：
10.1016/j.str.2013.08.005
发表时间：
2013-10-08
期刊：
Structure (London, England : 1993)
影响因子：
--
作者：
Song Y;DiMaio F;Wang RY;Kim D;Miles C;Brunette T;Thompson J;Baker D
通讯作者：
Baker D
肌钙蛋白 I 和 IC 对肌动蛋白-肌球蛋白亚片段 1 ATP 酶活性的抑制：与肌肉细丝状态的关系。
影响因子：
2.9
作者：
Geeves,MA;Chai,M;Lehrer,SS
通讯作者：
Lehrer,SS