Effects of spatially filtered fearful faces and awareness on amygdala activity in adults with autism spectrum disorder: A magnetoencephalography study
Effects of spatially filtered fearful faces and awareness on amygdala activity in adults with autism spectrum disorder: A magnetoencephalography study
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空间过滤的恐惧面孔和意识对自闭症谱系障碍成人杏仁核活动的影响：脑磁图研究
DOI：
10.1016/j.neulet.2023.137135
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发表时间：
2023
影响因子：
2.5
通讯作者：
Tobimatsu Shozo
中科院分区：
文献类型：
--
作者：
Maekawa Toshihiko;Kuroki Toshihide;Tanaka Mutsuhide;Ogata Katsuya;Yamasaki Takao;Matsubara Teppei;Tobimatsu Shozo
研究背景杏仁核在情绪面孔加工中起着关键作用。视觉图像的空间频率（SF）通过两条视觉通路进行划分和处理：低空间频率（LSF）信息由大细胞通路传递，而小细胞通路传递高空间频率信息。我们假设，杏仁核活动的改变可能会导致非典型的社会沟通的变化，在有意识和无意识的情绪面孔处理在大脑中的个体与自闭症谱系障碍（ASD）。MethodEighteen ASD和18个典型的发展（TD）的同龄人参加了这项研究。空间过滤的恐惧和中性表情的面孔和对象的刺激下，阈上或阈下的条件下，和杏仁核的神经磁反应进行了测量，使用306通道全头magnetoencephalography.ResultsThe潜伏期的诱发反应在约200 ms的未过滤的中性面孔刺激和对象的刺激在ASD组比TD组在不知情的条件下。在情绪面孔加工方面，在意识状态下，ASD组的诱发反应大于TD组。在200-500 ms（ARV）的后期正移大于TD组，无论意识。此外，ARV的HSF的脸刺激大于其他空间过滤的脸在aware condition. ConclusionNo意识，ARV可能反映了非典型的面孔信息加工的ASD大脑。
BackgroundThe amygdala is pivotal in emotional face processing. Spatial frequencies (SFs) of visual images are divided and processed via two visual pathways: low spatial frequency (LSF) information is conveyed by the magnocellular pathway, while the parvocellular pathway carries high spatial frequency information. We hypothesized that altered amygdala activity might underlie atypical social communication caused by changes in both conscious and non-conscious emotional face processing in the brain in individuals with autism spectrum disorder (ASD).MethodEighteen adults with ASD and 18 typically developing (TD) peers participated in this study. Spatially filtered fearful- and neutral-expression faces and object stimuli were presented under supraliminal or subliminal conditions, and neuromagnetic responses in the amygdala were measured using 306-channel whole-head magnetoencephalography.ResultsThe latency of the evoked responses at approximately 200 ms to unfiltered neutral face stimuli and object stimuli in the ASD group was shorter than that in the TD group in the unaware condition. Regarding emotional face processing, the evoked responses in the ASD group were larger than those in the TD group under the aware condition. The later positive shift during 200–500 ms (ARV) was larger than that in the TD group, regardless of awareness. Moreover, ARV to HSF face stimuli was larger than that to the other spatial filtered face stimuli in the aware condition.ConclusionRegardless of awareness, ARV might reflect atypical face information processing in the ASD brain.
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DOI：
--
发表时间：
2008
期刊：
影响因子：
--
作者：
浦野東洋一;勝野正章;中田康彦;編著;Masamichi Sakagami
通讯作者：
Masamichi Sakagami
高空间频率过滤素数加速了自闭症成人的笑脸分类
影响因子：
2.5
作者：
A. Lacroix;Ladislas Nalborczyk;F. Dutheil;K. Kovarski;S. Chokron;M. Garrido;M. Gomot;Martial Mermillod
通讯作者：
Martial Mermillod
影响因子：
2.6
作者：
Deruelle, C;Fagot, J
通讯作者：
Fagot, J
影响因子：
4.2
作者：
Hardee, Jillian E.;Thompson, James C.;Puce, Aina
通讯作者：
Puce, Aina
影响因子：
2.6
作者：
Fujimura, Tomomi;Umemura, Hiroyuki
通讯作者：
Umemura, Hiroyuki