Transcriptomic Regulations Underlying Pair-bond Formation and Maintenance in the Socially Monogamous Male and Female Prairie Vole.
Transcriptomic Regulations Underlying Pair-bond Formation and Maintenance in the Socially Monogamous Male and Female Prairie Vole.
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DOI：
10.1016/j.biopsych.2020.11.022
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发表时间：
2022-01-01
影响因子：
10.6
通讯作者：
Kabbaj M
中科院分区：
文献类型：
--
作者：
Duclot F;Sailer L;Koutakis P;Wang Z;Kabbaj M
形成持久的社会联系的能力是人性的特征，社会关系的损害是严重的神经精神障碍，包括自闭症谱系障碍和精神分裂症的主要特征。由于能够形成长期的配对关系，一夫一妻制的草原田鼠已经成为研究社会依恋神经生物学的一个很好的模型。然而，尽管这种结合具有持久的性质，但令人惊讶的是，在两性的配对结合过程中涉及的基因很少。雄性和雌性草原田鼠（Microtus ochrogaster）与异性伴侣同居24小时或3周（3W），并通过RNA测序测量了黑核（NAc）的转录调控。我们发现性别特异性的反应模式，尽管类似的行为指标对债券的建立。事实上，24小时的同居与异性伴侣引起广泛的转录组的变化，仍然在一定程度上持续在女性3W后，但返回到基线之前的第二组规则的男性。这导致了在3W处的高度性别偏见的NAc转录组，其与神经传递、蛋白质周转和DNA转录等过程相关。特别是，我们发现性别特异性改变的线粒体动力学同居后，在男性裂变的转变。除了确定基因，网络，和参与NAC的配对过程的途径，我们的工作说明了草原田鼠配对的分子机制的性别差异的巨大程度，并铺平了道路，以进一步了解复杂的社会结合过程。
The ability to form enduring social bonds is characteristic of human nature and impairments in social affiliation are central features of severe neuropsychiatric disorders including autism spectrum disorders and schizophrenia. Due to its ability to form long-term pair-bonds, the socially monogamous prairie vole has emerged as an excellent model to study the neurobiology of social attachment. Despite the enduring nature of the bond, however, surprisingly few genes have been implicated in the pair-bonding process in either sex. Male and female prairie voles (Microtus ochrogaster) were cohabitated with an opposite-sex partner for 24 hrs or 3 weeks (3W) and transcriptomic regulations in the nucleus accumbens (NAc) were measured by RNA-sequencing. We found sex-specific response patterns despite similar behavioral indicators of pair-bond establishment. Indeed, 24 hrs of cohabitation with an opposite-sex partner induced widespread transcriptomic changes that remained sustained to some extent in females after 3W but returned to baseline before a second set of regulations in males. This led to a highly sexually-biased NAc transcriptome at 3W related to processes such as neurotransmission, protein turnover, and DNA transcription. In particular, we found sex-specific alterations of mitochondrial dynamics following cohabitation, with a shift towards fission in males. In addition to identifying the genes, networks, and pathways involved in the pair-bonding process in the NAc, our work illustrates the vast extent of sex differences in the molecular mechanisms underlying pair-bonding in prairie voles, and paves the way to further our understanding of the complex social bonding process.
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影响因子：
48
作者：
Huber W;Carey VJ;Gentleman R;Anders S;Carlson M;Carvalho BS;Bravo HC;Davis S;Gatto L;Girke T;Gottardo R;Hahne F;Hansen KD;Irizarry RA;Lawrence M;Love MI;MacDonald J;Obenchain V;Oleś AK;Pagès H;Reyes A;Shannon P;Smyth GK;Tenenbaum D;Waldron L;Morgan M
通讯作者：
Morgan M
影响因子：
10.6
作者：
King LB;Walum H;Inoue K;Eyrich NW;Young LJ
通讯作者：
Young LJ
DOI：
10.1093/bioinformatics/btw216
发表时间：
2016-07-15
期刊：
Bioinformatics (Oxford, England)
影响因子：
--
作者：
Lachmann A;Giorgi FM;Lopez G;Califano A
通讯作者：
Califano A
WGCNA：用于加权相关网络分析的 R 包。
影响因子：
3
作者：
Langfelder P;Horvath S
通讯作者：
Horvath S
Trichostatin A（TSA）有助于雄性草原田鼠（Microtus ochrogaster）的伴侣偏好形成。
影响因子：
3.5
作者：
Duclot F;Wang H;Youssef C;Liu Y;Wang Z;Kabbaj M
通讯作者：
Kabbaj M