Sortilin receptor 1 predicts longitudinal cognitive change.
Sortilin receptor 1 predicts longitudinal cognitive change.
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DOI：
10.1016/j.neurobiolaging.2012.12.006
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发表时间：
2013-06
影响因子：
4.2
通讯作者：
Pedersen NL
中科院分区：
文献类型：
--
作者：
Reynolds CA;Zavala C;Gatz M;Vie L;Johansson B;Malmberg B;Ingelsson E;Prince JA;Pedersen NL
编码分拣蛋白受体1（SORL 1）的基因与阿尔茨海默病风险相关。我们检查了15个SORL 1变异和SNP设置的风险评分与纵向言语，空间，记忆和感知速度性能，测试年龄趋势和性别特异性影响。在16年的时间里，来自三项以人群为基础的瑞典双胞胎研究的1609名个体总共接受了5次评估。控制APOE，观察到空间，情节记忆和言语轨迹的多个简单和性别调节的关联（p = 1.25E-03至p = 4.83E-02）。5个变异体（rs 11600875、rs753780、rs7105365、rs 11820794、rs 2070045）在不同领域之间存在相关性。值得注意的是，在rs 2070045风险等位基因纯合子中，男性表现出最初良好的性能，但加速下降，而女性表现出整体较低的性能。SNP设置的风险评分预测空间（卡片旋转，p = 5.92E-03）和情景记忆轨迹（Thurstone图片记忆，p = 3.34E-02），其中较高的风险评分有利于男性与女性的表现，直到75岁，但加速下降。SORL 1与认知老化有关，可能对男性和女性的变化有不同的贡献。
The gene encoding sortilin receptor 1 (SORL1) has been associated with Alzheimer’s disease risk. We examined 15 SORL1 variants and SNP-set risk scores in relation to longitudinal verbal, spatial, memory and perceptual speed performance, testing for age trends and sex-specific effects. Altogether, 1609 individuals from three population-based Swedish twin studies were assessed up to five times across 16 years. Controlling for APOE, multiple simple and sex-moderated associations were observed for spatial, episodic memory and verbal trajectories (p = 1.25E-03 to p = 4.83E-02). Five variants (rs11600875, rs753780, rs7105365, rs11820794, rs2070045) were associated across domains. Notably, in those homozygous for rs2070045 risk alleles, males demonstrated initially favorable performance but accelerating declines, while females showed overall lower performance. SNP-set risk scores predicted spatial (Card Rotations, p = 5.92E-03) and episodic memory trajectories (Thurstone Picture Memory, p = 3.34E-02), where higher risk scores benefitted men’s versus women’s performance up to age 75 but with accelerating declines. SORL1 is associated with cognitive aging, and may contribute differentially to change in men and women.
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影响因子：
30.8
作者：
Marchini, Jonathan;Howie, Bryan;Donnelly, Peter
通讯作者：
Donnelly, Peter
影响因子：
4.2
作者：
McCarthy JJ;Saith S;Linnertz C;Burke JR;Hulette CM;Welsh-Bohmer KA;Chiba-Falek O
通讯作者：
Chiba-Falek O
影响因子：
1.9
作者：
Finkel, D;Pedersen, NL
通讯作者：
Pedersen, NL
影响因子：
2.5
作者：
Kimura, Ryo;Yamamoto, Mitsuko;Takeda, Masatoshi
通讯作者：
Takeda, Masatoshi
影响因子：
--
作者：
Houwing-Duistermaat, Jeanine J;Uh, Hae-Won;Tsonaka, Roula
通讯作者：
Tsonaka, Roula