RPS19 and TYMS SNPs and Prevalent High Risk Human Papilloma Virus Infection in Nigerian Women.
RPS19 and TYMS SNPs and Prevalent High Risk Human Papilloma Virus Infection in Nigerian Women.
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DOI：
10.1371/journal.pone.0066930
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发表时间：
2013
期刊：
影响因子：
3.7
通讯作者：
Adebamowo CA
中科院分区：
文献类型：
--
作者：
Famooto A;Almujtaba M;Dareng E;Akarolo-Anthony S;Ogbonna C;Offiong R;Olaniyan O;Wheeler CM;Doumatey A;Rotimi CN;Adeyemo A;Adebamowo CA
高危型HPV（hrHPV）感染是导致宫颈癌的一个必要因素，但其宿主遗传决定因素尚不清楚。我们招募了267名妇女，她们在2012年4月至2012年8月期间参加了尼日利亚阿布贾的宫颈癌筛查项目。我们收集了所有参与者的人口统计学特征、宫颈癌危险因素的信息，并获得了血液和宫颈脱落细胞样本。我们使用Roche Linear Array HPV Genotyping Test®根据制造商的说明来表征流行的HPV; Sequenom Mass Array测试先前与hrHPV相关的基因/区域中的21个SNP，并使用回归模型来检查与HPV感染相关的独立因素。我们认为p<0.05是显著的，因为这是一项重复研究。有65名妇女和202名妇女没有hrHPV感染。在等位基因模型下，我们发现RPS 19上的rs 2305809和TYMS上的rs 2342700这两个SNP与普遍的hrHPV感染之间存在显著关联。将年龄、体重指数、吸烟、初潮年龄、初次性行为年龄、一生性伴侣总数和妊娠总数作为协变量进行校正后，hrHPV风险的多变量分析得出rs 2305809和rs 2342700的p值分别为0.071和0.010。我们在这一独特人群中的发现表明，hrHPV的许多遗传风险变异与其他人群共享。需要更大样本量和使用全基因组方法的连续性研究，以了解多个人群中hrHPV风险的遗传结构。
High risk HPV (hrHPV) infection is a necessary cause of cervical cancer but the host genetic determinants of infection are poorly understood. We enrolled 267 women who presented to our cervical cancer screening program in Abuja, Nigeria between April 2012 and August 2012. We collected information on demographic characteristics, risk factors of cervical cancer and obtained samples of blood and cervical exfoliated cells from all participants. We used Roche Linear Array HPV Genotyping Test® to characterize the prevalent HPV according to manufacturer's instruction; Sequenom Mass Array to test 21 SNPs in genes/regions previously associated with hrHPV and regression models to examine independent factors associated with HPV infection. We considered a p<0.05 as significant because this is a replication study. There were 65 women with and 202 women without hrHPV infection. Under the allelic model, we found significant association between two SNPs, rs2305809 on RPS19 and rs2342700 on TYMS, and prevalent hrHPV infection. Multivariate analysis of hrHPV risk adjusted for age, body mass index, smoking, age of menarche, age at sexual debut, lifetime total number of sexual partners and the total number of pregnancies as covariates, yielded a p-value of 0.071 and 0.010 for rs2305809 and rs2342700, respectively. Our findings in this unique population suggest that a number of genetic risk variants for hrHPV are shared with other population groups. Definitive studies with larger sample sizes and using genome wide approaches are needed to understand the genetic architecture of hrHPV risk in multiple populations.
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发表时间：
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影响因子：
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