Variants in exon 11 of MEF2A gene and coronary artery disease: evidence from a case-control study, systematic review, and meta-analysis.
Variants in exon 11 of MEF2A gene and coronary artery disease: evidence from a case-control study, systematic review, and meta-analysis.
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MEF2A 基因外显子 11 的变异与冠状动脉疾病：来自病例对照研究、系统评价和荟萃分析的证据。
DOI：
10.1371/journal.pone.0031406
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发表时间：
2012
期刊：
影响因子：
3.7
通讯作者：
Jin W
中科院分区：
文献类型：
--
作者：
Liu Y;Niu W;Wu Z;Su X;Chen Q;Lu L;Jin W
Coronary artery disease (CAD) is the most common heart disease worldwide. Association of CAD with variants in the myocyte enhancer factor 2A (MEF2A) gene, the first identified CAD-causing gene, has attracted special attention but the results are controversial. We aimed to evaluate this genetic association via a case-control study and meta-analysis. We performed a case-control association study to investigate the relationship between variations in exon 11 of MEF2A gene and CAD in 1045 sporadic patients and 1008 controls enrolled angiographically among southern Chinese population, and then the data from this study were compared and discussed in a systematic review and meta-analysis with all available published studies on MEF2A gene and CAD. In total, eight variants were identified (21-bp deletion, CAG repeats, CCG repeats, a CCA deletion and four SNPs). No significant link was observed between the common (CAG)n polymorphism and CAD, whereas the rare 21-bp deletion was detected only in five affected individuals. The meta-analysis of (CAG)n polymorphism and CAD risk, including nine studies with 3801 CAD patients and 4020 controls, also provided no convincing evidence for the genetic association, even upon stratification by race (mainly Whites and Chinese). However, the 21-bp deletion was regarded as a potentially logical, albeit undetermined, candidate for CAD in the following systematic review. Our findings failed to demonstrate a correlation between (CAG)n polymorphism with CAD, however, we concluded that the rare 21-bp deletion might have a more compelling effect on CAD than the common (CAG)n polymorphism, and MEF2A genetic variant might be a rare but specific cause of CAD/MI.
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影响因子：
5.3
作者：
Elhawari, Samar;Al-Boudari, Olyan;Dzimiri, Nduna
通讯作者：
Dzimiri, Nduna
影响因子：
7
作者：
Cohn, LD;Becker, BJ
通讯作者：
Becker, BJ
影响因子：
2.9
作者：
Hsu, Lung-An;Chang, Chi-Jen;Ko, Yu-Lin
通讯作者：
Ko, Yu-Lin
影响因子：
6.8
作者：
Han, Yaling;Yang, Yong;Kang, Jian
通讯作者：
Kang, Jian
DOI：
10.1016/0197-2456(86)90046-2
发表时间：
1986-09-01
期刊：
CONTROLLED CLINICAL TRIALS
影响因子：
--
作者：
DERSIMONIAN, R;LAIRD, N
通讯作者：
LAIRD, N