Prevalence of vertebral fracture in women and the relationship with bone density and symptoms: The chingford study
Prevalence of vertebral fracture in women and the relationship with bone density and symptoms: The chingford study
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女性椎骨骨折的患病率及其与骨密度和症状的关系：chingford 研究
DOI：
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发表时间：
1993
影响因子：
6.2
通讯作者：
J. Kanis
中科院分区：
文献类型：
--
作者：
T. Spector;E. McCloskey;D. Doyle;J. Kanis
进行了一项人口调查，以估计 45-69 岁女性椎骨骨折的患病率，并确定其与骨密度和症状的关系。受试者为 1035 名 45-69 岁的女性（平均 55.4 岁，应答率为 77%），来自伦敦 Chingford 一家拥有 11,000 人的大型全科诊所的年龄性别登记册。通过半自动定量方法读取胸椎和腰椎 X 射线。椎骨骨折的诊断采用多种形态测量方法，包括我们最近开发的新方法以及 Melton 和 Eastell 发表的方法。这些方法都检测前部、中央或后部椎骨高度之间以及观察到的后部椎骨高度与从相邻椎骨后部高度预测的值之间的异常比率。采用双能 X 射线骨密度仪 (DXA) 测量腰椎 L1-4 和股骨颈的骨密度 (BMD)。使用我们的方法，1035 名女性中有 147 名（14.2%，95% CI 12.0-16.2%）患有轻微骨折（至少有两个椎骨比率低于平均值 2-2.99 SD），占总数的 20 名，1.9%（95% CI 1.2-3.0%）患有严重骨折（至少有两个椎骨比率低于平均值 3 SD 以上）。在 147 名患有轻微骨折的女性中，脊柱骨密度并没有明显低于其他 868 名女性，并且报告的背痛或身高下降并不常见。患有多处轻微骨折的女性骨密度确实较低，低了 0.4 个标准差。在 20 名患有严重骨折的女性中，骨密度显着降低，降低了 0.6 个标准差。身高下降更为常见，但背痛则不然。使用 Melton 方法，畸形患病率为 10.2%，而使用 Eastell 3 和 4 SD 方法，畸形患病率分别为 9.7% 和 1.3%，这与罗彻斯特人群公布的数据相似。轻微的椎骨畸形在绝经后女性中很常见，但它们通常与疼痛、身高下降或（除非是多发性）骨密度降低相关。这表明它们可能不具有临床或病理重要性。在 70 岁以下的英国女性中，与骨密度低相关的严重畸形很少见。
A population survey was performed to estimate the prevalence of vertebral fractures in women aged 45–69 and to determine their relationship to bone density and symptoms. Subjects were 1035 women aged 45–69 (mean 55.4 years, response rate 77%) from the age‐sex register of a large 11,000‐person general practice in Chingford, London. Thoracic and lumbar spine x‐rays were read by a semiautomated quantitative method. Vertebral fractures were diagnosed using a variety of morphometric methods, including a new method we recently developed and the published methods of Melton and Eastell. These methods all detect abnormal ratios between anterior, central, or posterior vertebral height and between observed posterior vertebral height and values predicted from the posterior height of adjacent vertebrae. Bone mineral density (BMD) of lumbar spine L1–4 and neck of femur was measured by dual‐energy x‐ray absorptiometry (DXA). Using our method, 147, 14.2% (95% CI 12.0–16.2%) of the 1035 women, had minor fractures (at least two vertebral ratios 2–2.99 SD below the mean) and 20, 1.9% (95% CI 1.2–3.0%) of the total, had severe fractures (at least two ratios more than 3 SD below the mean). In the 147 women with minor fractures, bone density of the spine was not significantly lower than in the other 868 women, and reported back pain or loss of height was no more common. Women with multiple minor fractures did have lower bone density, by 0.4 SD. In the 20 women with severe fracture, bone density was significantly lower, by 0.6 SD. Loss of height was more common, but back pain was not. Using the method of Melton the prevalence of deformity was 10.2% and, for the Eastell 3 and 4 SD method, 9.7 and 1.3%, respectively, which is similar to published data from the Rochester population. Minor vertebral deformities are common in postmenopausal women, but they are not usually associated with pain, loss of height, or (unless multiple) reduced bone density. This suggests that they may not be of clinical or pathologic importance. Severe deformities associated with low bone density are rare in U.K. women under the age of 70.
影响因子：
5
作者：
MELTON, LJ;KAN, SH;RIGGS, BL
通讯作者：
RIGGS, BL