Development of Molecular Magnetic Resonance Imaging Tools for Longitudinal Tracking of Carotid Atherosclerotic Disease Using Fast Imaging with Steady-State Precession.
Development of Molecular Magnetic Resonance Imaging Tools for Longitudinal Tracking of Carotid Atherosclerotic Disease Using Fast Imaging with Steady-State Precession.
复制标题
基于稳态进动快速成像的颈动脉粥样硬化疾病分子磁共振成像工具的发展。
DOI：
10.1007/s12975-022-01067-8
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发表时间：
2023-06
影响因子：
6.9
通讯作者：
Chan, Joyce M. S.
中科院分区：
文献类型：
--
作者：
Park, Sung-Jin;Chan, Wan Ying;Ng, Michael;Chung, Yiu Cho;Chong, Tze Tec;Bhakoo, Kishore;Chan, Joyce M. S.
关键词：
识别具有高风险无症状颈动脉斑块的患者仍然是预防中风的一个具有挑战性但至关重要的步骤。目前颈动脉疾病干预的选择标准仍然是根据症状和管腔狭窄程度来确定。这种策略在识别高危无症状个体患者方面效果较差。炎症是导致斑块不稳定并导致临床后遗症的关键因素。目前，常规临床实践中还没有成像工具来评估动脉粥样硬化斑块内的炎症状态。在此，我们描述了一种新型分子磁共振成像（MRI）策略的开发，该策略使用基于双靶向铁颗粒的探针和稳态进动（FISP）序列的快速成像来询问斑块炎症及其在体内的脆弱性，为单独的管腔狭窄添加了进一步的预后信息。在载脂蛋白 E 缺陷小鼠模型中，使用动脉周围袖带在颈动脉的特定时间点和位置生成高风险斑块。使用该平台，我们证明了具有增强型 FISP 的体内双靶向铁颗粒可以（i）靶向并表征高风险易损斑块，以及（ii）纵向定量报告和跟踪颈动脉斑块内的炎症活动。这种分子成像工具可以（i）准确监测颈动脉斑块的风险，（ii）及时识别高危无症状患者进行预防性颈动脉干预，实现早期卒中预防。
Identification of patients with high-risk asymptomatic carotid plaques remains a challenging but essential step in stroke prevention. Current selection criteria for intervention in carotid disease are still determined by symptomatology and degree of luminal stenosis. This strategy has been less effective in identifying the high-risk asymptomatic individual patients. Inflammation is the key factor that drives plaque instability causing clinical sequelae. Currently, there is no imaging tool in routine clinical practice to assess the inflammatory status within atherosclerotic plaques. Herein we describe the development of a novel molecular magnetic resonance imaging (MRI) strategy to interrogate plaque inflammation, and hence its vulnerability in vivo, using dual-targeted iron particle-based probes and fast imaging with steady-state precession (FISP) sequence, adding further prognostic information to luminal stenosis alone. A periarterial cuff was used to generate high-risk plaques at specific timepoints and location of the carotid artery in an apolipoprotein-E-deficient mouse model. Using this platform, we demonstrated that in vivo dual-targeted iron particles with enhanced FISP can (i) target and characterise high-risk vulnerable plaques and (ii) quantitatively report and track the inflammatory activity within carotid plaques longitudinally. This molecular imaging tool may permit (i) accurate monitoring of the risk of carotid plaques and (ii) timely identification of high-risk asymptomatic patients for prophylactic carotid intervention, achieving early stroke prevention.
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影响因子：
11.2
作者：
Marnane, Michael;Merwick, Aine;Kelly, Peter J.
通讯作者：
Kelly, Peter J.
影响因子：
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作者：
Kassem M;Florea A;Mottaghy FM;van Oostenbrugge R;Kooi ME
通讯作者：
Kooi ME
影响因子：
2.4
作者：
Benes, V;Netuka, D;Kramár, F
通讯作者：
Kramár, F
影响因子：
8.3
作者：
Shalhoub, Joseph;Monaco, Claudia;Davies, Alun H.
通讯作者：
Davies, Alun H.
影响因子：
3.3
作者：
Hänicke, W;Vogel, HU
通讯作者：
Vogel, HU