Magnetic resonance imaging of carotid plaques: current status and clinical perspectives.
Magnetic resonance imaging of carotid plaques: current status and clinical perspectives.
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DOI：
10.21037/atm-2020-cass-16
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发表时间：
2020-10
影响因子：
--
通讯作者：
Kooi ME
中科院分区：
文献类型：
--
作者：
Kassem M;Florea A;Mottaghy FM;van Oostenbrugge R;Kooi ME
易损的颈动脉斑块破裂是中风的主要原因之一。颈动脉磁共振成像（MRI）能够可视化斑块易损性的所有主要标志。在过去的二十年中，各种MRI序列已被开发用于量化颈动脉斑块的负担和组成。通常，使用多个序列的组合。这些MRI技术已经通过颈动脉内膜切除术标本的组织学分析得到了广泛的验证。MRI与斑块负荷、斑块内出血（IPH）、富含脂质的坏死核心（LRNC）、纤维帽（FC）状态、炎症和新生血管的组织学测量结果高度一致。新的MRI序列允许产生三维各向同性图像与大的纵向覆盖。其他新序列可以使用单个序列获得多个对比，从而大大减少扫描时间。IPH可以很容易地在强t1加权图像上识别为斑块中大块的高信号，例如用标准神经血管线圈在几分钟内获得的磁化制备的快速采集梯度回声图像。颈动脉MRI也可用于评估治疗效果。几项荟萃分析表明，IPH、LRNC、FC变薄或破裂对缺血性脑血管事件具有很强的预测价值。最近，在一项基于无症状和有症状的颈动脉狭窄个体患者数据的大型荟萃分析中，显示MRI上的IPH是卒中的独立风险预测因子，比任何已知的临床风险参数都强。最近在一份白皮书中描述了有关颈动脉斑块MRI协议的专家建议。本文综述了颈动脉斑块MR成像的现状、应用及其在日常临床实践中的潜力。
Rupture of a vulnerable carotid plaque is one of the leading causes of stroke. Carotid magnetic resonance imaging (MRI) is able to visualize all the main hallmarks of plaque vulnerability. Various MRI sequences have been developed in the last two decades to quantify carotid plaque burden and composition. Often, a combination of multiple sequences is used. These MRI techniques have been extensively validated with histological analysis of carotid endarterectomy specimens. High agreement between the MRI and histological measures of plaque burden, intraplaque hemorrhage (IPH), lipid-rich necrotic core (LRNC), fibrous cap (FC) status, inflammation and neovascularization has been demonstrated. Novel MRI sequences allow to generate three-dimensional isotropic images with a large longitudinal coverage. Other new sequences can acquire multiple contrasts using a single sequence leading to a tremendous reduction in scan time. IPH can be easily identified as a hyperintense signal in the bulk of the plaque on strongly T1-weighted images, such as magnetization-prepared rapid acquisition gradient echo images, acquired within a few minutes with a standard neurovascular coil. Carotid MRI can also be used to evaluate treatment effects. Several meta-analyses have demonstrated a strong predictive value of IPH, LRNC, thinning or rupture of the FC for ischemic cerebrovascular events. Recently, in a large meta-analysis based on individual patient data of asymptomatic and symptomatic individuals with carotid artery stenosis, it was shown that IPH on MRI is an independent risk predictor for stroke, stronger than any known clinical risk parameter. Expert recommendations on carotid plaque MRI protocols have recently been described in a white paper. The present review provides an overview of the current status and applications of carotid plaque MR imaging and its future potential in daily clinical practice.
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DOI：
10.3174/ajnr.a2213
发表时间：
2010-09
期刊：
AJNR. American journal of neuroradiology
影响因子：
--
作者：
Demarco JK;Ota H;Underhill HR;Zhu DC;Reeves MJ;Potchen MJ;Majid A;Collar A;Talsma JA;Potru S;Oikawa M;Dong L;Zhao X;Yarnykh VL;Yuan C
通讯作者：
Yuan C
影响因子：
4.4
作者：
Cappendijk, Vincent C.;Kessels, Alfons G. H.;Kooi, M. Eline
通讯作者：
Kooi, M. Eline
DOI：
10.1016/j.ejvs.2014.01.017
发表时间：
2014-05-01
影响因子：
5.7
作者：
Chan, J. M. S.;Monaco, C.;Gibbs, R. G. J.
通讯作者：
Gibbs, R. G. J.
影响因子：
19.7
作者：
Altaf, Nishath;Goode, Stephen D.;Auer, Dorothee P.
通讯作者：
Auer, Dorothee P.
利用同步非造影血管造影和斑块内出血 (SNAP) 技术评估颈动脉粥样硬化斑块表面特征。
DOI：
10.1002/jmri.25815
发表时间：
2018-03
期刊：
Journal of magnetic resonance imaging : JMRI
影响因子：
--
作者：
Chen S;Zhao H;Li J;Zhou Z;Li R;Balu N;Yuan C;Chen H;Zhao X
通讯作者：
Zhao X