The Role of Endothelial-to-Mesenchymal Transition in Cardiovascular Disease.
The Role of Endothelial-to-Mesenchymal Transition in Cardiovascular Disease.
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内皮-间质转化（EndoMT）是内皮细胞逐渐失去内皮特异性标记并获得间质表型的过程。在正常生理条件下，EndoMT 在形成发育中的心脏瓣膜方面发挥着基础作用。然而，EndoMT 会导致各种心血管疾病 (CVD) 的发生，例如动脉粥样硬化、瓣膜疾病、纤维化和肺动脉高压 (PAH)。因此，更深入地了解 CVD 中 EndoMT 的细胞和分子机制应该为扭转这种情况提供迫切需要的见解。这篇综述总结了 30 年的相关文献，特别描述了 EndoMT 过程、关键信号通路以及 CVD 涉及的基础调控网络。
Endothelial-to-mesenchymal transition (EndoMT) is the process of endothelial cells progressively losing endothelial-specific markers and gaining mesenchymal phenotypes. In the normal physiological condition, EndoMT plays a fundamental role in forming the cardiac valves of the developing heart. However, EndoMT contributes to the development of various cardiovascular diseases (CVD), such as atherosclerosis, valve diseases, fibrosis, and pulmonary arterial hypertension (PAH). Therefore, a deeper understanding of the cellular and molecular mechanisms underlying EndoMT in CVD should provide urgently needed insights into reversing this condition. This review summarizes a 30-year span of relevant literature, delineating the EndoMT process in particular, key signaling pathways, and the underlying regulatory networks involved in CVD.
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影响因子：
12.4
作者：
Chen Q;Shou P;Zheng C;Jiang M;Cao G;Yang Q;Cao J;Xie N;Velletri T;Zhang X;Xu C;Zhang L;Yang H;Hou J;Wang Y;Shi Y
通讯作者：
Shi Y
影响因子：
4
作者：
Correia, Ana C. P.;Moonen, Jan-Renier A. J.;Krenning, Guido
通讯作者：
Krenning, Guido
影响因子：
8.8
作者：
Chen PY;Qin L;Barnes C;Charisse K;Yi T;Zhang X;Ali R;Medina PP;Yu J;Slack FJ;Anderson DG;Kotelianski V;Wang F;Tellides G;Simons M
通讯作者：
Simons M
影响因子：
20.1
作者：
Bischoff J;Casanovas G;Wylie-Sears J;Kim DH;Bartko PE;Guerrero JL;Dal-Bianco JP;Beaudoin J;Garcia ML;Sullivan SM;Seybolt MM;Morris BA;Keegan J;Irvin WS;Aikawa E;Levine RA
通讯作者：
Levine RA
影响因子：
2.7
作者：
Boyer, AS;Ayerinskas, II;Runyan, RB
通讯作者：
Runyan, RB