Synthetic lethal approaches to target cancers with loss of PTEN function.
Synthetic lethal approaches to target cancers with loss of PTEN function.
复制标题
DOI：
10.1016/j.gendis.2022.12.015
复制
发表时间：
2023-11
期刊：
影响因子：
6.8
通讯作者：
Wang Y
中科院分区：
文献类型：
--
作者：
Ertay A;Ewing RM;Wang Y
磷酸酶和紧张素同源物（PTEN）是一种肿瘤抑制基因，通过将磷脂酰肌醇3,4,5-三磷酸（PIP3）去磷酸化为磷脂酰肌醇4,5-二磷酸（PIP2），抑制致癌AKT信号通路。PTEN的功能受到不同机制的调控，PTEN失活导致侵袭性肿瘤表型和肿瘤发生。确定针对非活性肿瘤抑制基因（如PTEN）的靶向治疗一直具有挑战性，因为很难恢复肿瘤抑制功能。因此，关注下游信号通路以发现非活性肿瘤抑制基因的靶向治疗，凸显了合成致死率研究的重要性。本文综述了在pten失活型癌症中发现的潜在的合成致死性基因。这些发现的基因可能成为pten非活性癌症类型的潜在靶向治疗方法，并可能提高侵袭性癌症类型的治疗反应率。
Phosphatase and tensin homolog (PTEN) is a tumour suppressor gene and has a role in inhibiting the oncogenic AKT signalling pathway by dephosphorylating phosphatidylinositol 3,4,5-triphosphate (PIP3) into phosphatidylinositol 4,5-bisphosphate (PIP2). The function of PTEN is regulated by different mechanisms and inactive PTEN results in aggressive tumour phenotype and tumorigenesis. Identifying targeted therapies for inactive tumour suppressor genes such as PTEN has been challenging as it is difficult to restore the tumour suppressor functions. Therefore, focusing on the downstream signalling pathways to discover a targeted therapy for inactive tumour suppressor genes has highlighted the importance of synthetic lethality studies. This review focuses on the potential synthetic lethality genes discovered in PTEN-inactive cancer types. These discovered genes could be potential targeted therapies for PTEN-inactive cancer types and may improve the treatment response rates for aggressive types of cancer.
登录
查看更多内容
影响因子：
8.2
作者：
Wong, J. T.;Kim, P. T. W.;Peacock, J. W.;Yau, T. Y.;Mui, A. L. -F.;Chung, S. W.;Sossi, V.;Doudet, D.;Green, D.;Ruth, T. J.;Parsons, R.;Verchere, C. B.;Ong, C. J.
通讯作者：
Ong, C. J.
影响因子：
8.8
作者：
Chatterjee, Nilanjana;Pazarentzos, Evangelos;Bivona, Trever G.
通讯作者：
Bivona, Trever G.
影响因子：
45.3
作者：
Dawood, Shaheenah;Broglio, Kristine;Giordano, Sharon H.
通讯作者：
Giordano, Sharon H.
影响因子：
21.3
作者：
van Diepen, Michiel T.;Parsons, Maddy;Downes, C. Peter;Leslie, Nicholas R.;Hindges, Robert;Eickholt, Britta J.
通讯作者：
Eickholt, Britta J.
影响因子：
4.7
作者：
Chow, Jimmy Y. C.;Quach, Khai T.;Carethers, John M.
通讯作者：
Carethers, John M.