Modular Organization of Signal Transmission in Primate Somatosensory Cortex.
Modular Organization of Signal Transmission in Primate Somatosensory Cortex.
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DOI：
10.3389/fnana.2022.915238
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发表时间：
2022
影响因子：
2.9
通讯作者：
中科院分区：
文献类型：
--
作者：
轴突斑被认为是高等哺乳动物大脑皮层突触连接的主要部位。然而，这些补丁的功能作用备受争议。斑块是由附近的神经元群体以地形方式形成的，被认为是皮层区域内和皮层区域之间长距离横向连接的终止场。此外，轴突在斑块外部形成大量的纽扣，其功能也是未知的。为了更好地理解这两个不同群体的功能作用，我们通过新世界猴体感皮层的纤维束追踪，比较了区域内、前馈和反馈通路斑块内外轴突的个体和集体形态特征。我们发现，除了作为不变属性的弯曲度之外，补丁域内的轴突和无补丁域内的轴突之间的布顿间距和轴突收敛属性显着不同。主成分分析证实了根据斑块形成的轴突聚类，而没有受到路径类型或层状分布的任何额外影响。逐步逻辑回归将收敛性和布顿密度确定为斑块形成的最佳预测因子。这些发现支持斑块是轴突汇聚的特定位点，促进神经元群的同步活动。另一方面，无补丁域可以形成神经解剖学基质，使皮质神经元的反应多样化。
Axonal patches are known as the major sites of synaptic connections in the cerebral cortex of higher order mammals. However, the functional role of these patches is highly debated. Patches are formed by populations of nearby neurons in a topographic manner and are recognized as the termination fields of long-distance lateral connections within and between cortical areas. In addition, axons form numerous boutons that lie outside the patches, whose function is also unknown. To better understand the functional roles of these two distinct populations of boutons, we compared individual and collective morphological features of axons within and outside the patches of intra-areal, feedforward, and feedback pathways by way of tract tracing in the somatosensory cortex of New World monkeys. We found that, with the exception of tortuosity, which is an invariant property, bouton spacing and axonal convergence properties differ significantly between axons within patch and no-patch domains. Principal component analyses corroborated the clustering of axons according to patch formation without any additional effect by the type of pathway or laminar distribution. Stepwise logistic regression identified convergence and bouton density as the best predictors of patch formation. These findings support that patches are specific sites of axonal convergence that promote the synchronous activity of neuronal populations. On the other hand, no-patch domains could form a neuroanatomical substrate to diversify the responses of cortical neurons.
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影响因子：
3.1
作者：
Innocenti, Giorgio M.;Caminiti, Roberto
通讯作者：
Caminiti, Roberto
影响因子：
3
作者：
Chavane F;Sharon D;Jancke D;Marre O;Frégnac Y;Grinvald A
通讯作者：
Grinvald A
影响因子：
2.5
作者：
Friedman, Robert M.;Chen, Li Min;Roe, Anna W.
通讯作者：
Roe, Anna W.
影响因子：
5.3
作者：
Binzegger, Tom;Douglas, Rodney J.;Martin, Kevan A. C.
通讯作者：
Martin, Kevan A. C.
影响因子：
3.7
作者：
Bauer, Roman;Zubler, Frederic;Douglas, Rodney J.
通讯作者：
Douglas, Rodney J.