Chinese SLE treatment and research group registry: III. association of autoantibodies with clinical manifestations in Chinese patients with systemic lupus erythematosus.
Chinese SLE treatment and research group registry: III. association of autoantibodies with clinical manifestations in Chinese patients with systemic lupus erythematosus.
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DOI：
10.1155/2014/809389
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发表时间：
2014
影响因子：
4.1
通讯作者：
Zeng X
中科院分区：
文献类型：
--
作者：
Li J;Leng X;Li Z;Ye Z;Li C;Li X;Zhu P;Wang Z;Zheng Y;Li X;Zhang M;Tian XP;Li M;Zhao J;Zhang FC;Zhao Y;Zeng X
我们通过分析来自CSTAR队列登记资料的2104例SLE患者的特异性自身抗体与临床表现的关系，探讨中国SLE患者的特征。抗sm抗体、抗rnp抗体与疟疾皮疹呈显著相关（P < 0.05）；抗rnp抗体、抗ssa抗体与肺动脉高压（PAH）的关系；抗ssb抗体与血液学受累的关系；抗dsdna抗体与肾病之间的关系。APL抗体与血液学累及、间质性肺疾病和较低的口腔溃疡患病率相关（P < 0.05）。抗dsdna抗体与较低的光敏患病率、抗ssa抗体与较低的肾病患病率之间也存在关联（P < 0.05）。这些发现大多与文献中的其他研究一致，但本研究是首次报道抗ssa与肾病发病率降低之间的关系。特异性自身抗体与临床表现的相关性可为医生预测SLE患者器官损害提供线索。我们建议，在确定SLE诊断后，应进行彻底的自身抗体筛查，对抗rnp或抗ssa抗体的SLE患者应每年进行多次超声心动图检查。
We investigated the characteristics of Chinese SLE patients by analyzing the association between specific autoantibodies and clinical manifestations of 2104 SLE patients from registry data of CSTAR cohort. Significant (P < 0.05) associations were found between anti-Sm antibody, anti-rRNP antibody, and malar rash; between anti-RNP antibody, anti-SSA antibody, and pulmonary arterial hypertension (PAH); between anti-SSB antibody and hematologic involvement; and between anti-dsDNA antibody and nephropathy. APL antibody was associated with hematologic involvement, interstitial lung disease, and a lower prevalence of oral ulcerations (P < 0.05). Associations were also found between anti-dsDNA antibody and a lower prevalence of photosensitivity, and between anti-SSA antibody and a lower prevalence of nephropathy (P < 0.05). Most of these findings were consistent with other studies in the literature but this study is the first report on the association between anti-SSA and a lower prevalence of nephropathy. The correlations of specific autoantibodies and clinical manifestations could provide clues for physicians to predict organ damages in SLE patients. We suggest that a thorough screening of autoantibodies should be carried out when the diagnosis of SLE is established, and repeated echocardiography annually in SLE patients with anti-RNP or anti-SSA antibody should be performed.
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影响因子：
2.6
作者：
Li, M.;Zhang, W.;Zeng, X.
通讯作者：
Zeng, X.
影响因子：
2.6
作者：
Borba, E. F.;Araujo, D. B.;Shinjo, S. K.
通讯作者：
Shinjo, S. K.
影响因子：
158.5
作者：
Arbuckle, MR;McClain, MT;Harley, JB
通讯作者：
Harley, JB
影响因子：
3.6
作者：
Cruse, JM;Lewis, RE;Dilioglou, S
通讯作者：
Dilioglou, S
影响因子：
4
作者：
SACHSE, C;LUTHKE, K;STANNATKIESSLING, S
通讯作者：
STANNATKIESSLING, S