Effects of abomasal infusion of long-chain fatty acids on splanchnic metabolism of pancreatic and gut hormones in lactating dairy cows.
Effects of abomasal infusion of long-chain fatty acids on splanchnic metabolism of pancreatic and gut hormones in lactating dairy cows.
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长链脂肪酸的真胃输注对泌乳奶牛胰腺和肠道激素内脏代谢的影响。
DOI：
10.3168/jds.s0022-0302(01)70182-8
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发表时间：
2001
影响因子：
3.5
通讯作者：
C. K. Reynolds
中科院分区：
文献类型：
--
作者：
J. Benson;C. K. Reynolds
胰激素和肠肽激素是干物质摄入量 (DMI) 减少的潜在介质，通常在饲喂补充脂肪的泌乳奶牛中观察到。我们研究了 7 天的皱胃输注菜籽和葵花籽油混合物（主要提供不饱和长链脂肪酸 (LCFA)）对胰岛素、胰 (PAN) 和肠 (GUT) 胰高血糖素、胰高血糖素样肽-1 (7-36) 酰胺 (GLP-1) 和胆囊收缩素的动脉浓度和内脏（门引流内脏 [PDV] 和肝脏）代谢的影响(CCK) 在产后 55 (ELAC) 和 111 (MLAC) d 的六头奶牛中进行。 ELAC 中 PDV 和肝脏的血浆流量更大，并且通过输油而增加。 MLAC 中胰岛素和 PAN 的动脉浓度较高，而 ELAC 中 GLP-1 和 CCK 的动脉浓度较高。皱胃油输注增加了GUT和GLP-1的动脉浓度，但降低了动脉胰岛素浓度。外周激素浓度的这些差异很大程度上是由于其净 PDV 释放和（或）肝脏清除的变化造成的。此外，输油可增加肝脏对 PAN 的净清除量。输油对 CCK 的内脏代谢或动脉浓度没有影响。 MLAC 中 CCK 浓度较低可归因于净肝脏去除，这强调了肝脏代谢在确定肠道和胰肽激素外周浓度中的重要性。这项研究的结果表明，胰高血糖素原加工产物（PAN、GUT 和 GLP-1）作为 LCFA 瘤后供应引起的 DMI 减少的调节剂发挥着作用。
Pancreatic and gut peptide hormones are potential mediators of the reduction in dry matter intake (DMI) often observed in lactating dairy cows fed supplemental fat. We investigated the effects of 7-d abomasal infusions of a rapeseed and sunflower oil mixture providing mostly unsaturated long-chain fatty acids (LCFA) on arterial concentration and splanchnic (portal-drained viscera [PDV] and liver) metabolism of insulin, pancreatic (PAN) and gut (GUT) glucagon, glucagon-like peptide-1 (7-36) amide (GLP-1), and cholecystokinin (CCK) in six cows at 55 (ELAC) and 111 (MLAC) d postpartum. Plasma flow for the PDV and liver were greater in ELAC and increased by oil infusion. Arterial concentrations of insulin and PAN were greater in MLAC, whereas arterial concentrations of GLP-1 and CCK were greater in ELAC. Abomasal oil infusion increased arterial concentration of GUT and GLP-1 but decreased arterial insulin concentration. These differences in peripheral hormone concentration were due largely to changes in their net PDV release and (or) liver removal. In addition, net liver removal of PAN was increased by oil infusion. There was no effect of oil infusion on splanchnic metabolism or arterial concentration of CCK. Lower concentrations of CCK in MLAC were attributable to net liver removal, emphasizing the importance of liver metabolism in determining peripheral concentrations of gut and pancreatic peptide hormones. Results of this study suggest a role for products of proglucagon processing (PAN, GUT, and GLP-1) as mediators of the reduction in DMI caused by postruminal supply of LCFA.
影响因子：
20.3
作者：
M. Schwartz;D. Figlewicz;D. Baskin;S. Woods;D. Porte
通讯作者：
M. Schwartz;D. Figlewicz;D. Baskin;S. Woods;D. Porte
影响因子：
--
作者：
LIDDLE, RA;GREEN, GM;WILLIAMS, JA
通讯作者：
WILLIAMS, JA