Polymorphisms in immune mediators associate with risk of cervical cancer.
Polymorphisms in immune mediators associate with risk of cervical cancer.
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DOI：
10.1016/j.ygyno.2014.07.106
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发表时间：
2014-10
影响因子：
4.7
通讯作者：
Rader JS
中科院分区：
文献类型：
--
作者：
Zhang Z;Fye S;Borecki IB;Rader JS
免疫系统对控制HPV宫颈疾病的进展和癌症的发展至关重要。本研究旨在确定候选免疫调节基因中的宫颈癌易感等位基因。我们以家庭为基础的研究包括641名先证者（患有ICC / CIN III的女性）及其亲生父母或兄弟姐妹（641名三人组）。在发现阶段（第一阶段），涉及288个三组，在GoldenGate平台上评估了11个免疫调节基因（IFNG, IFNGR1, IFNGR2, JAK1, JAK2, STAT1, STAT6, IL12A， TNF， LTA和LTB）的81个标签单核苷酸多态性（snp）。我们使用了总共641个trios（阶段2）的组合数据集和Taqman平台来验证在发现数据集中证明重要的snp。传输不平衡测试用于检测数据集中等位基因传输的显著变化。JAK2的两个SNP和STAT6的一个SNP在1期发现数据集中显示与宫颈癌有显著的等位基因关联，并在更大的联合分析2期数据集中得到重复（JAK2 rs10815144, P = 0.0029, rs12349785, P = 0.0058; STAT6 rs3024971, P = 0.0127）。由于JAK2外显子19的另一个SNP （rs2230724）与rs10815144的强连锁不平衡（LD），我们也在组合数据集中检查了它。差异有统计学意义（P=0.0335）。我们的研究结果表明JAK2和STAT6的snp与宫颈癌有关。这种关联应该在更多的宫颈癌人群中进行调查。
The immune system is critical for controlling the progression of HPV cervical disease and the development of cancer. This study aimed to identify cervical cancer susceptibility alleles in candidate immune-modulating genes. Our family-based study involved a cohort of 641 probands (women with ICC / CIN III) and their biologic parents or siblings (641 trios). In the discovery phase (stage 1), involving 288 of the trios, 81 tag single nucleotide polymorphisms (SNPs) in 11 immune-modulating genes (IFNG, IFNGR1, IFNGR2, JAK1, JAK2, STAT1, STAT6, IL12A, TNF, LTA and LTB) were evaluated on the GoldenGate platform. We used the combined dataset for a total of 641 trios (stage 2) and the Taqman platform to validate the SNPs that had proved significant in the discovery dataset. The transmission disequilibrium test was used to detect significant shifts in allelic transmissions in the datasets. Two SNPs in JAK2 and one SNP in STAT6 showed significant allelic association with cervical cancer in the stage 1 discovery dataset and were replicated in the larger joint analysis stage 2 dataset (JAK2 rs10815144, P = 0.0029 and rs12349785, P = 0.0058; and STAT6 rs3024971, P = 0.0127). An additional SNP in exon 19 of JAK2 (rs2230724) was also examined in the combined dataset due to its strong linkage disequilibrium (LD) with rs10815144. It was also significant (P=0.0335). Our results suggest an association of SNPs in JAK2 and STAT6 with cervical cancer. This association should be investigated in additional cervical cancer populations.
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影响因子：
4.7
作者：
Bodelon, Clara;Madeleine, Margaret M.;Schwartz, Stephen M.
通讯作者：
Schwartz, Stephen M.
DOI：
10.1073/pnas.0901329106
发表时间：
2009-06-02
影响因子：
11.1
作者：
Critchley-Thorne, Rebecca J.;Simons, Diana L.;Lee, Peter P.
通讯作者：
Lee, Peter P.
影响因子：
32.4
作者：
Stark GR;Darnell JE Jr
通讯作者：
Darnell JE Jr
人类宫颈癌发生过程中不断演变的免疫抑制微环境
影响因子：
8
作者：
Kobayashi, A.;Weinberg, V.;Smith-McCune, K.
通讯作者：
Smith-McCune, K.
影响因子：
30.8
作者：
Skol, AD;Scott, LJ;Boehnke, M
通讯作者：
Boehnke, M