Metformin Enhances Excitatory Synaptic Transmission onto Hippocampal CA1 Pyramidal Neurons.
Metformin Enhances Excitatory Synaptic Transmission onto Hippocampal CA1 Pyramidal Neurons.
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二甲双胍增强海马 CA1 锥体神经元的兴奋性突触传递
DOI：
10.3390/brainsci10100706
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发表时间：
2020-10-04
期刊：
影响因子：
3.3
通讯作者：
Fei EK
中科院分区：
文献类型：
--
作者：
Chen WB;Chen J;Liu ZY;Luo B;Zhou T;Fei EK
Metformin (Met) is a first-line drug for type 2 diabetes mellitus (T2DM). Numerous studies have shown that Met exerts beneficial effects on a variety of neurological disorders, including Alzheimer’s disease (AD), Parkinson’s disease (PD) and Huntington’s disease (HD). However, it is still largely unclear how Met acts on neurons. Here, by treating acute hippocampal slices with Met (1 μM and 10 μM) and recording synaptic transmission as well as neuronal excitability of CA1 pyramidal neurons, we found that Met treatments significantly increased the frequency of miniature excitatory postsynaptic currents (mEPSCs), but not amplitude. Neither frequency nor amplitude of miniature inhibitory postsynaptic currents (mIPSCs) were changed with Met treatments. Analysis of paired-pulse ratios (PPR) demonstrates that enhanced presynaptic glutamate release from terminals innervating CA1 hippocampal pyramidal neurons, while excitability of CA1 pyramidal neurons was not altered. Our results suggest that Met preferentially increases glutamatergic rather than GABAergic transmission in hippocampal CA1, providing a new insight on how Met acts on neurons.
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DOI：
10.1073/pnas.1517045112
发表时间：
2015-12-15
影响因子：
11.1
作者：
Chen, Xiaobing;Levy, Jonathan M.;Reese, Thomas S.
通讯作者：
Reese, Thomas S.
影响因子：
7.4
作者：
Li, Wenjun;Chaudhari, Kiran;Yang, Shao-Hua
通讯作者：
Yang, Shao-Hua
影响因子：
3.1
作者：
Gasser PJ;Hurley MM;Chan J;Pickel VM
通讯作者：
Pickel VM
影响因子：
3.3
作者：
Patil, S. P.;Jain, P. D.;Sathaye, S.
通讯作者：
Sathaye, S.
影响因子：
2
作者：
Biag, Hazel Maridith B.;Potter, Laura A.;Hagerman, Randi J.
通讯作者：
Hagerman, Randi J.