Hypoxic tumor microenvironment and cancer cell differentiation.
Hypoxic tumor microenvironment and cancer cell differentiation.
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DOI：
10.2174/156652409788167113
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发表时间：
2009-05
影响因子：
2.5
通讯作者：
Yun Z
中科院分区：
文献类型：
--
作者：
Kim Y;Lin Q;Glazer PM;Yun Z
缺氧或缺氧是实体瘤的显著特征。低氧肿瘤通常对常规癌症疗法具有抗性，并且肿瘤低氧与恶性肿瘤的晚期阶段相关。低分化肿瘤似乎分化较差。越来越多的证据表明，缺氧具有抑制肿瘤细胞分化的潜力，因此在维持肿瘤干细胞中起直接作用。研究还表明，缺氧阻断间充质干/祖细胞的分化，间充质干/祖细胞是肿瘤相关基质细胞的潜在来源。因此，缺氧可能对肿瘤间质微环境的演变产生深远影响。这些观察结果导致了缺氧在促进肿瘤进展中的作用的新范例的出现。缺氧可能有助于创造一个微环境，在低分化的肿瘤细胞和未分化的基质细胞丰富。这种未分化的缺氧微环境可以提供必要的细胞相互作用和环境信号，用于优先维持癌症干细胞。这一假设表明，有效靶向低氧癌症干细胞是成功控制肿瘤的关键。
Hypoxia or oxygen deficiency is a salient feature of solid tumors. Hypoxic tumors are often resistant to conventional cancer therapies, and tumor hypoxia correlates with advanced stages of malignancy. Hypoxic tumors appear to be poorly differentiated. Increasing evidence suggests that hypoxia has the potential to inhibit tumor cell differentiation and thus plays a direct role in the maintenance of cancer stem cells. Studies have also shown that hypoxia blocks differentiation of mesenchymal stem/progenitor cells, a potential source of tumor-associated stromal cells. It is therefore likely that hypoxia may have a profound impact on the evolution of the tumor stromal microenvironment. These observations have led to the emergence of a novel paradigm for a role of hypoxia in facilitating tumor progression. Hypoxia may help create a microenvironment enriched in poorly differentiated tumor cells and undifferentiated stromal cells. Such an undifferentiated hypoxic microenvironment may provide essential cellular interactions and environmental signals for the preferential maintenance of cancer stem cells. This hypothesis suggests that effectively targeting hypoxic cancer stem cells is a key to successful tumor control.
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