Longitudinal analysis of the relationship between motor and psychiatric symptoms in idiopathic dystonia.
Longitudinal analysis of the relationship between motor and psychiatric symptoms in idiopathic dystonia.
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DOI：
10.1111/ene.15530
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发表时间：
2022-12
影响因子：
5.1
通讯作者：
中科院分区：
文献类型：
--
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虽然精神病诊断是公认的特发性肌张力障碍，没有以前的研究探讨特发性肌张力障碍和精神病诊断之间的时间关系的规模。在这里，我们确定了与匹配的对照组相比，诊断为特发性肌张力障碍的患者的精神病诊断率和精神病药物处方率。在威尔士（英国）使用匿名电子医疗保健数据进行了一项基于人群的纵向队列研究，以确定1994年1月1日至2017年12月31日期间患有特发性肌张力障碍和共病精神病诊断/处方的个体。从初级和二级卫生保健记录中确定精神病诊断/处方。与对照组相比，特发性肌张力障碍患者（n = 52，589）的精神病诊断率和精神病药物处方率更高（n = 216，754，43% vs. 31%，p < 0.001; 45% vs. 37.9%，p < 0.001），抑郁和焦虑最常见（病例：31%和28%）。精神病诊断主要早于肌张力障碍诊断，尤其是在诊断前12个月（发生率比[IRR] = 1.98，95%置信区间[CI] = 1.9-2.1），焦虑症的IRR为12.4（95% CI = 11.8-13.1）。然而，在整个研究期间，包括肌张力障碍诊断后的12个月，大多数精神病诊断率升高（IRR = 1.96，95% CI = 1.85-2.07）。这项研究表明，精神疾病和肌张力障碍，特别是情绪障碍之间的双向关系。肌张力障碍的精神和运动症状可能有共同的病因机制，精神疾病可能形成特发性肌张力障碍的前驱症状。与对照组相比，特发性肌张力障碍患者的精神病诊断率和精神病药物处方率较高，其中抑郁和焦虑最为常见。精神病学诊断主要早于肌张力障碍诊断，特别是在诊断前12个月。然而，在整个研究期间，包括肌张力障碍诊断后的12个月，大多数精神病诊断率升高，表明精神疾病和肌张力障碍之间存在双向关系。
Although psychiatric diagnoses are recognized in idiopathic dystonia, no previous studies have examined the temporal relationship between idiopathic dystonia and psychiatric diagnoses at scale. Here, we determine rates of psychiatric diagnoses and psychiatric medication prescription in those diagnosed with idiopathic dystsuponia compared to matched controls. A longitudinal population‐based cohort study using anonymized electronic health care data in Wales (UK) was conducted to identify individuals with idiopathic dystonia and comorbid psychiatric diagnoses/prescriptions between 1 January 1994 and 31 December 2017. Psychiatric diagnoses/prescriptions were identified from primary and secondary health care records. Individuals with idiopathic dystonia (n = 52,589) had higher rates of psychiatric diagnosis and psychiatric medication prescription when compared to controls (n = 216,754, 43% vs. 31%, p < 0.001; 45% vs. 37.9%, p < 0.001, respectively), with depression and anxiety being most common (cases: 31% and 28%). Psychiatric diagnoses predominantly predated dystonia diagnosis, particularly in the 12 months prior to diagnosis (incidence rate ratio [IRR] = 1.98, 95% confidence interval [CI] = 1.9–2.1), with an IRR of 12.4 (95% CI = 11.8–13.1) for anxiety disorders. There was, however, an elevated rate of most psychiatric diagnoses throughout the study period, including the 12 months after dystonia diagnosis (IRR = 1.96, 95% CI = 1.85–2.07). This study suggests a bidirectional relationship between psychiatric disorders and dystonia, particularly with mood disorders. Psychiatric and motor symptoms in dystonia may have common aetiological mechanisms, with psychiatric disorders potentially forming prodromal symptoms of idiopathic dystonia. Individuals with idiopathic dystonia had higher rates of psychiatric diagnosis and psychiatric medication prescription when compared to controls, with depression and anxiety being most common. Psychiatric diagnoses predominantly predated dystonia diagnosis, particularly in the 12 months prior to diagnosis. There was, however, an elevated rate of most psychiatric diagnoses throughout the study period, including the 12 months after dystonia diagnosis, suggesting a bidirectional relationship between psychiatric disorders and dystonia.
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影响因子：
4.5
作者：
Lee, Sze Chim;DelPozo-Banos, Marcos;John, Ann
通讯作者：
John, Ann
影响因子：
8.6
作者：
LaHue, Sara C.;Albers, Kathleen;Goldman, Samuel;Lo, Raymond;Gu, Zhuqin;Leimpeter, Amethyst;Fross, Robin;Comyns, Kathleen;Marras, Connie;de Kleijn, Annelie;Smit, Robin;Katz, Maya;Ozelius, Laurie J.;Bressman, Susan;Saunders-Pullman, Rachel;Comella, Cynthia;Klingman, Jeffrey;Nelson, Lorene M.;Van Den Eeden, Stephen K.;Tanner, Caroline M.
通讯作者：
Tanner, Caroline M.
DOI：
10.1007/s00406-020-01189-w
发表时间：
2022-03
影响因子：
4.7
作者：
Fusar-Poli L;Brondino N;Politi P;Aguglia E
通讯作者：
Aguglia E
影响因子：
8.6
作者：
Albanese, Alberto;Bhatia, Kailash;Bressman, Susan B.;DeLong, Mahlon R.;Fahn, Stanley;Fung, Victor S. C.;Hallett, Mark;Jankovic, Joseph;Jinnah, Hyder A.;Klein, Christine;Lang, Anthony E.;Mink, Jonathan W.;Teller, Jan K.
通讯作者：
Teller, Jan K.
影响因子：
81.5
作者：
Balint, Bettina;Mencacci, Niccolo E.;Bhatia, Kailash P.
通讯作者：
Bhatia, Kailash P.