The dynamics of autism spectrum disorders: how neurotoxic compounds and neurotransmitters interact.
The dynamics of autism spectrum disorders: how neurotoxic compounds and neurotransmitters interact.
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DOI：
10.3390/ijerph10083384
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发表时间：
2013-08-06
影响因子：
--
通讯作者：
Van de Bor M
中科院分区：
文献类型：
--
作者：
Quaak I;Brouns MR;Van de Bor M
近年来，人们越来越关注自闭症谱系障碍（ASD）的患病率。越来越多的证据表明，接触神经毒性化合物与ASD有关。神经递质可能发挥关键作用，因为研究表明神经毒性化合物，神经递质和ASD之间存在联系。在目前的审查文献综述方面的神经毒性暴露和对神经递质系统的影响。目的是确定可能导致ASD的机制和相关因素。在本综述中报道的文献支持这样的假设，即暴露于神经毒性化合物可导致GABA能、多巴胺能、多巴胺能和多巴胺能系统的改变，这些系统在以前的工作中与ASD相关。然而，在几项研究中，报告的结果并不支持这一假设。其他因素也可能与此相关，可能会改变工作机制，例如暴露的时间和长度以及化合物的剂量。未来的研究应侧重于确定这些因素与神经毒性化合物暴露相互作用的途径，利用人体研究。
In recent years concern has risen about the increasing prevalence of Autism Spectrum Disorders (ASD). Accumulating evidence shows that exposure to neurotoxic compounds is related to ASD. Neurotransmitters might play a key role, as research has indicated a connection between neurotoxic compounds, neurotransmitters and ASD. In the current review a literature overview with respect to neurotoxic exposure and the effects on neurotransmitter systems is presented. The aim was to identify mechanisms and related factors which together might result in ASD. The literature reported in the current review supports the hypothesis that exposure to neurotoxic compounds can lead to alterations in the GABAergic, glutamatergic, serotonergic and dopaminergic system which have been related to ASD in previous work. However, in several studies findings were reported that are not supportive of this hypothesis. Other factors also might be related, possibly altering the mechanisms at work, such as time and length of exposure as well as dose of the compound. Future research should focus on identifying the pathway through which these factors interact with exposure to neurotoxic compounds making use of human studies.
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