Auditory lexical-semantic processing impairments in aphasic patients reflected in event-related potentials (N400).
Auditory lexical-semantic processing impairments in aphasic patients reflected in event-related potentials (N400).
复制标题
失语症患者的听觉词汇语义处理损伤反映在事件相关电位（N400）中。
DOI：
10.1016/j.anl.2003.07.007
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发表时间：
2003
期刊：
影响因子：
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通讯作者：
K. Kaga
中科院分区：
文献类型：
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作者：
Tomoyuki Kojima;K. Kaga
目的记录伴有听觉语言处理障碍的失语受试者和年龄匹配的正常对照者在执行词汇-语义评价任务时的事件相关电位（event - correlation potential, erp）和反应潜伏期，旨在阐明事件相关电位是否可以作为判断失语患者语言障碍的可靠指标。方法采用50对口语单词（启动词-目标词）进行刺激，其中25对语义和/或联想相关，25对语义和/或联想不相关。当目标词与启动词在语义上相关时，被试按下开关。本研究分析的ERP成分为N400。结果在表演过程中，失语组的反应潜伏期明显长于正常对照组。与正常对照相比，在ERPs的作用下，失语患者N400的发病潜伏期被推迟。对于失语症患者，N400的大小与失语症测试中评估的听觉理解表现存在相关性。结论N400效应可能是衡量失语患者词汇-语义判断任务的反应潜伏期和轻度词汇-语义障碍严重程度的可靠临床指标。
ObjectiveEvent-related potentials (ERPs) and response latencies were recorded from aphasic subjects with auditory language processing impairments and age-matched normal controls, while performing a lexical-semantic evaluation task, aiming at clarifying whether ERPs could be a reliable measure for indicating language impairments in aphasic patients.MethodsThe stimuli were 50 pairs of spoken words (prime word–target word): 25 pairs, which were semantically and/or associatively related to each other, and 25 pairs which were not. The subjects pressed a switch in response to the presentation of target words semantically related to the prime words. The ERP component analyzed in this study was N400.ResultsWith the performances, the response latencies were longer in the aphasic subjects than in the normal controls. With the ERPs, onset latencies of N400 were shifted behind in the aphasic patients compared to the normal controls. For the aphasic patients, there were correlations between the size of N400 and performances in auditory comprehension evaluated in the aphasia test.ConclusionThe conclusions drawn from the results are that not only response latencies in the lexical-semantic judgement task, but also N400 effects, may be a reliable clinical measure of the severity of even mild lexical-semantic impairments in aphasic patients.
影响因子：
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作者：
MEYER, DE;SCHVANEVELDT, RW
通讯作者：
SCHVANEVELDT, RW