Aberrant crypt foci as precursors in colorectal cancer progression.
Aberrant crypt foci as precursors in colorectal cancer progression.
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DOI：
10.1002/jso.21106
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发表时间：
2008-09-01
影响因子：
2.5
通讯作者：
Alrawi, Sadir J.
中科院分区：
文献类型：
--
作者：
Orlando, Frank A.;Tan, Dongfeng;Baltodano, Juan D.;Khoury, Thaer;Gibbs, John F.;Hassid, Victor J.;Ahmed, Bestoun H.;Alrawi, Sadir J.
Colorectal cancer progression originates when accumulated genetic and epigenetic alterations cause genomic instability and a malignant phenotype. Subsequent molecular pathway deregulation leads to histopathologic changes that are clinically evident as aberrant crypt foci (ACF) and visualized by high-magnification chromoscopic colonoscopy. ACF are biomarkers of increased colorectal cancer risk, particularly those with dysplastic features. Genetic profiling using genomic instability, loss of heterozygosity, and methylation analysis has revealed a minority population of ACF genotypically analogous to cancer.
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