Pros and cons of inhibiting cholesteryl ester transfer protein
Pros and cons of inhibiting cholesteryl ester transfer protein
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抑制胆固醇酯转移蛋白的利弊
DOI：
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发表时间：
2000
影响因子：
4.4
通讯作者：
Y. Matsuzawa
中科院分区：
文献类型：
--
作者：
K. Hirano;S. Yamashita;Y. Matsuzawa
自从胆固醇酯转运蛋白（CETP）基因缺陷被发现以来，是否需要抑制CETP一直是一个重要的问题，最近，在日本和西方国家报道的一些流行病学研究有助于阐明CETP基因突变或多态性的人类受试者的动脉粥样硬化性。此外，一些实验性动脉粥样硬化的研究，其中CETP被抑制在兔用不同的方法，已被报道。人CETP缺乏和CETP抑制兔的致动脉粥样硬化性有相当大的差异。本文就CETP在胆固醇逆向转运中的作用进行综述，并对CETP在胆固醇逆向转运中的作用进行探讨。
Whether or not it is desirable to inhibit cholesteryl ester transfer protein (CETP) has been an important question for over fifteen years since genetic CETP deficiency was found. Recently, some epidemiological studies which have been reported in Japan as well as Western countries help to clarify the atherogenicity of human subjects with mutations or polymorphisms in the CETP gene. In addition, some experimental atherosclerosis studies, in which CETP was inhibited in rabbits with different approaches, have been reported. There was a considerable difference in the atherogenicity of human CETP deficiency and CETP-inhibited rabbits. In this review, we summarize the recent advances in this field as well as discussing the significance of CETP in reverse cholesterol transport, a major protective system against atherosclerosis.
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影响因子：
6.5
作者：
X. Collet;A. Tall;H. Serajuddin;K. Guendouzi;L. Royer;H. Oliveira;R. Barbaras;Xian-Cheng Jiang;O. Francone
通讯作者：
X. Collet;A. Tall;H. Serajuddin;K. Guendouzi;L. Royer;H. Oliveira;R. Barbaras;Xian-Cheng Jiang;O. Francone
影响因子：
8.7
作者：
Ordovas, JM;Cupples, LA;Schaefer, EJ
通讯作者：
Schaefer, EJ
影响因子：
6.5
作者：
C. Bruce;D. Sharp;A. Tall
通讯作者：
C. Bruce;D. Sharp;A. Tall
影响因子：
15.9
作者：
HAYEK, T;MASUCCIMAGOULAS, L;TALL, AR
通讯作者：
TALL, AR
影响因子：
15.9
作者：
Luo, Y;Tall, AR
通讯作者：
Tall, AR