Brain state-dependent abnormal LFP activity in the auditory cortex of a schizophrenia mouse model.
Brain state-dependent abnormal LFP activity in the auditory cortex of a schizophrenia mouse model.
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DOI：
10.3389/fnins.2014.00168
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发表时间：
2014
影响因子：
4.3
通讯作者：
Nakazawa K
中科院分区：
文献类型：
--
作者：
Nakao K;Nakazawa K
在精神分裂症中，诱发的40 Hz听觉稳态反应（ASSR）受损，这反映了这种疾病的感觉缺陷，基线自发振荡活动也出现异常。引起的ASSR损伤是否是由于基线功率的可能增加引起的一直存在争议。GABA能神经元间特异性NMDA受体（NMDAR）功能低下突变小鼠模拟精神分裂症的某些行为和病理生理学方面。为了确定这些突变小鼠的感觉缺陷的存在和程度，我们记录了自发的局部场电位（LFP）活动及其点击列车诱发的ASSR从清醒的，头部受限的小鼠的初级听觉皮层。基线自发LFP功率在预刺激期前的应用程序的第一个点击列车在很宽的频率范围内增加。然而，当每20秒重复一次ASSR刺激时，突变小鼠在ASSR刺激间隔期间的平均自发LFP功率振幅与对照小鼠的水平变得难以区分。尽管如此，诱发的40-Hz ASSR功率和他们的相位锁定点击列车在突变体中受到强烈损害，虽然诱发的20-Hz ASSR也有所减少。这些结果表明，皮层GABA能神经元的NMDAR功能减退赋予听觉皮层两种脑状态依赖性LFP异常：（1）在没有外部输入的情况下自发LFP功率的宽带增加;（2）在重复听觉刺激期间，尽管基线LFP功率幅值正常，但诱发ASSR功率及其锁相的稳健缺陷。在没有外界刺激的情况下，初级听觉皮层自发性的高LFP活动可能有助于精神分裂症相关异常听觉感知的出现。
In schizophrenia, evoked 40-Hz auditory steady-state responses (ASSRs) are impaired, which reflects the sensory deficits in this disorder, and baseline spontaneous oscillatory activity also appears to be abnormal. It has been debated whether the evoked ASSR impairments are due to the possible increase in baseline power. GABAergic interneuron-specific NMDA receptor (NMDAR) hypofunction mutant mice mimic some behavioral and pathophysiological aspects of schizophrenia. To determine the presence and extent of sensory deficits in these mutant mice, we recorded spontaneous local field potential (LFP) activity and its click-train evoked ASSRs from primary auditory cortex of awake, head-restrained mice. Baseline spontaneous LFP power in the pre-stimulus period before application of the first click trains was augmented at a wide range of frequencies. However, when repetitive ASSR stimuli were presented every 20 s, averaged spontaneous LFP power amplitudes during the inter-ASSR stimulus intervals in the mutant mice became indistinguishable from the levels of control mice. Nonetheless, the evoked 40-Hz ASSR power and their phase locking to click trains were robustly impaired in the mutants, although the evoked 20-Hz ASSRs were also somewhat diminished. These results suggested that NMDAR hypofunction in cortical GABAergic neurons confers two brain state-dependent LFP abnormalities in the auditory cortex; (1) a broadband increase in spontaneous LFP power in the absence of external inputs, and (2) a robust deficit in the evoked ASSR power and its phase-locking despite of normal baseline LFP power magnitude during the repetitive auditory stimuli. The “paradoxically” high spontaneous LFP activity of the primary auditory cortex in the absence of external stimuli may possibly contribute to the emergence of schizophrenia-related aberrant auditory perception.
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影响因子：
3.7
作者：
Hakami T;Jones NC;Tolmacheva EA;Gaudias J;Chaumont J;Salzberg M;O'Brien TJ;Pinault D
通讯作者：
Pinault D
影响因子：
4.6
作者：
Caixeta FV;Cornélio AM;Scheffer-Teixeira R;Ribeiro S;Tort AB
通讯作者：
Tort AB
影响因子：
3.3
作者：
Ehrlichman, R. S.;Gandal, M. J.;Siegel, S. J.
通讯作者：
Siegel, S. J.
影响因子：
6.6
作者：
Ford, Judith M.;Mathalon, Daniel H.
通讯作者：
Mathalon, Daniel H.
DOI：
10.1073/pnas.0609440103
发表时间：
2006-12-26
影响因子：
11.1
作者：
Cho, R. Y.;Konecky, R. O.;Carter, C. S.
通讯作者：
Carter, C. S.