Identification of novel inducible nuclear factors that interact with the acute phase responsive promoter element of rabbit alpha 1-acid glycoprotein gene.
Identification of novel inducible nuclear factors that interact with the acute phase responsive promoter element of rabbit alpha 1-acid glycoprotein gene.
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鉴定与兔α1-酸性糖蛋白基因的急性期反应启动子元件相互作用的新型诱导核因子。
DOI：
10.1016/0006-291x(92)90239-h
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发表时间：
1992
影响因子：
3.1
通讯作者：
Ray,A
中科院分区：
文献类型：
--
作者：
Ray,BK;Ray,A
Alpha1-acid glycoprotein (α1-AGP) is a major acute phase protein that is highly inducible during hepatic acute-phase response. To identify the promoter element(s) required for increased gene transcription under acute condition a 529 bp 5′-flanking region ofα1-AGP gene is fused to the chloramphenicol acetyl transferase (CAT) reporter gene and introduced into BNL liver cells. This DNA fragment is capable of inducing synthesis of the reporter gene-product about ten-fold when transfected cells are exposed to conditioned medium from lipopolysaccharide-stimulated peripheral monocytes. Deletion analyses have shown that sequences located between -224 to-22 are capable of eliciting this inducible promoter function. Using electromobility shift assay we have identified two novel inducible nuclear factors from turpentine-induced acute liver that can interact with this regulatory promoter region. Our results indicate that binding of these two factors to the promoter region ofα1-AGP gene is highly specific in nature and the induction of this gene under acute condition may involve their participation.
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大鼠α1-酸性糖蛋白。
DOI：
--
发表时间：
1985
期刊：
The Journal of biological chemistry
影响因子：
--
作者：
Reinke,R;Feigelson,P
通讯作者：
Feigelson,P
DOI：
10.1111/j.1749-6632.1982.tb22124.x
发表时间：
1982-01-01
影响因子：
5.2
作者：
KUSHNER, I
通讯作者：
KUSHNER, I
用于真核启动子/增强子研究的改进表达载体。
影响因子：
2.7
作者：
Fridovich-Keil,JL;Gudas,JM;Bryan,IB;Pardee,AB
通讯作者：
Pardee,AB
兔α1-酸性糖蛋白编码互补DNA的分子克隆及核苷酸序列
DOI：
10.1016/0006-291x(91)90136-u
发表时间：
1991
影响因子：
3.1
作者：
B. Ray;A. Ray
通讯作者：
A. Ray
兔 α1 酸性糖蛋白基因组 DNA 的克隆和结构表征
DOI：
--
发表时间：
1992
期刊：
影响因子：
--
作者：
B. Ray;A. Ray
通讯作者：
A. Ray