The Influence of Higher-Order Epistasis on Biological Fitness Landscape Topography.
The Influence of Higher-Order Epistasis on Biological Fitness Landscape Topography.
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DOI：
10.1007/s10955-018-1975-3
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发表时间：
2018
影响因子：
1.6
通讯作者：
Heckendorn RB
中科院分区：
文献类型：
--
作者：
Weinreich DM;Lan Y;Jaffe J;Heckendorn RB
突变对生物体的影响通常取决于其基因组中已经存在的其他突变。遗传学家将这种突变相互作用称为上位性。成对上位效应已经被认识了超过一个世纪，它们的进化意义也受到了理论上的关注。然而，成对上位相互作用本身可以随基因组背景而变化。这被称为高阶上位性，它对进化的影响还不太清楚。在这里，我们评估的影响，高阶上位对地形的16个出版，生物健身景观。我们发现，平均而言，它们对健身景观的影响随顺序下降，并建议这种趋势的显着例外可能值得实验审查。最后，我们强调进一步的理论和实验工作解剖的影响，上位性的所有订单健身景观地形和自然选择的进化效率的机会。本文的在线版本（10.1007/s10955-018-1975-3）包含补充材料，可供授权用户使用。
The effect of a mutation on the organism often depends on what other mutations are already present in its genome. Geneticists refer to such mutational interactions as epistasis. Pairwise epistatic effects have been recognized for over a century, and their evolutionary implications have received theoretical attention for nearly as long. However, pairwise epistatic interactions themselves can vary with genomic background. This is called higher-order epistasis, and its consequences for evolution are much less well understood. Here, we assess the influence that higher-order epistasis has on the topography of 16 published, biological fitness landscapes. We find that on average, their effects on fitness landscape declines with order, and suggest that notable exceptions to this trend may deserve experimental scrutiny. We conclude by highlighting opportunities for further theoretical and experimental work dissecting the influence that epistasis of all orders has on fitness landscape topography and on the efficiency of evolution by natural selection. The online version of this article (10.1007/s10955-018-1975-3) contains supplementary material, which is available to authorized users.
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DOI：
10.1126/science.1162327
发表时间：
2009-06-26
期刊：
Science (New York, N.Y.)
影响因子：
--
作者：
Badis G;Berger MF;Philippakis AA;Talukder S;Gehrke AR;Jaeger SA;Chan ET;Metzler G;Vedenko A;Chen X;Kuznetsov H;Wang CF;Coburn D;Newburger DE;Morris Q;Hughes TR;Bulyk ML
通讯作者：
Bulyk ML
影响因子：
6.8
作者：
Heckendorn, Robert B.;Whitley, Darrell
通讯作者：
Whitley, Darrell
影响因子：
10.7
作者：
Brown, Kyle M.;Costanzo, Marna S.;Hartl, Daniel L.
通讯作者：
Hartl, Daniel L.
影响因子：
3.3
作者：
da Silva, Jack;Coetzer, Mia;Mosier, Donald E.
通讯作者：
Mosier, Donald E.
影响因子：
4.5
作者：
Crawford, Lorin;Zeng, Ping;Zhou, Xiang
通讯作者：
Zhou, Xiang