Genetic background affects susceptibility to tumoral stem cell reprogramming.
Genetic background affects susceptibility to tumoral stem cell reprogramming.
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DOI：
10.4161/cc.25544
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发表时间：
2013-08-01
期刊：
影响因子：
--
通讯作者：
Sánchez-García I
中科院分区：
文献类型：
--
作者：
García-Ramírez I;Ruiz-Roca L;Martín-Lorenzo A;Blanco O;García-Cenador MB;García-Criado FJ;Vicente-Dueñas C;Sánchez-García I
The latest studies of the interactions between oncogenes and its target cell have shown that certain oncogenes may act as passengers to reprogram tissue-specific stem/progenitor cell into a malignant cancer stem cell state. In this study, we show that the genetic background influences this tumoral stem cell reprogramming capacity of the oncogenes using as a model the Sca1-BCRABLp210 mice, where the type of tumor they develop, chronic myeloid leukemia (CML), is a function of tumoral stem cell reprogramming. Sca1-BCRABLp210 mice containing FVB genetic components were significantly more resistant to CML. However, pure Sca1-BCRABLp210 FVB mice developed thymomas that were not seen in the Sca1-BCRABLp210 mice into the B6 background. Collectively, our results demonstrate for the first time that tumoral stem cell reprogramming fate is subject to polymorphic genetic control.
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影响因子：
11.4
作者：
Vicente-Duenas, Carolina;Romero-Camarero, Isabel;Gonzalez-Herrero, Ines;Alonso-Escudero, Esther;Abollo-Jimenez, Fernando;Jiang, Xiaoyu;Gutierrez, Norma C.;Orfao, Alberto;Marin, Nieves;Maria Villar, Luisa;Fernandez Criado, Ma Carmen;Pintado, Belen;Flores, Teresa;Alonso-Lopez, Diego;De Las Rivas, Javier;Jimenez, Rafael;Garcia Criado, Francisco Javier;Garcia Cenador, Maria Begona;Lossos, Izidore S.;Cobaleda, Cesar;Sanchez-Garcia, Isidro
通讯作者：
Sanchez-Garcia, Isidro
影响因子：
20.3
作者：
Chu, Su;McDonald, Tinisha;Bhatia, Ravi
通讯作者：
Bhatia, Ravi
影响因子：
4.3
作者：
Vicente-Duenas, Carolina;Perez-Caro, Maria;Sanchez-Garcia, Isidro
通讯作者：
Sanchez-Garcia, Isidro
影响因子：
--
作者：
Vicente-Dueñas C;Barajas-Diego M;Romero-Camarero I;González-Herrero I;Flores T;Sánchez-García I
通讯作者：
Sánchez-García I
影响因子：
20.3
作者：
Kumari, Ashu;Brendel, Cornelia;Burchert, Andreas
通讯作者：
Burchert, Andreas