Microfluidic Strategies for Understanding the Mechanics of Cells and Cell-Mimetic Systems.
Microfluidic Strategies for Understanding the Mechanics of Cells and Cell-Mimetic Systems.
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DOI：
10.1146/annurev-chembioeng-061114-123407
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发表时间：
2015
影响因子：
8.4
通讯作者：
Kumar S
中科院分区：
文献类型：
--
作者：
Dahl JB;Lin JM;Muller SJ;Kumar S
微流控系统在高通量测量细胞生物物理特性和构建工程化细胞微环境方面正引起越来越多的关注。在这里，我们回顾了最近的应用微流控技术的力学活细胞和合成细胞模拟系统。我们开始讨论使用微流控装置来剖析细胞模拟物的力学，如胶囊和囊泡。然后，我们探索应用于循环细胞，包括红细胞和其他正常血细胞，以及具有潜在疾病诊断价值的罕见人群，如循环肿瘤细胞。最后，我们讨论了如何微流控装置已被用来调查的力学，趋化性，和侵入性迁移的粘附细胞。在这些方面，微流体技术代表了一个越来越重要的工具箱，用于以高通量和适合临床翻译的形式研究细胞力学和运动性。
Microfluidic systems are attracting increasing interest for the high-throughput measurement of cellular biophysical properties and for the creation of engineered cellular microenvironments. Here we review recent applications of microfluidic technologies to the mechanics of living cells and synthetic cell-mimetic systems. We begin by discussing the use of microfluidic devices to dissect the mechanics of cellular mimics such as capsules and vesicles. We then explore applications to circulating cells, including erythrocytes and other normal blood cells, and rare populations with potential disease diagnostic value, such as circulating tumor cells. We conclude by discussing how microfluidic devices have been used to investigate the mechanics, chemotaxis, and invasive migration of adherent cells. In these ways, microfluidic technologies represent an increasingly important toolbox for investigating cellular mechanics and motility at high throughput and in a format that lends itself to clinical translation.
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影响因子：
2.8
作者：
Davidson, Patricia M.;Denais, Celine;Bakshi, Maya C.;Lammerding, Jan
通讯作者：
Lammerding, Jan
影响因子：
8.6
作者：
Abkarian, M;Lartigue, C;Viallat, A
通讯作者：
Viallat, A
影响因子：
4.8
作者：
Balzer, Eric M.;Tong, Ziqiu;Konstantopoulos, Konstantinos
通讯作者：
Konstantopoulos, Konstantinos
影响因子：
7.4
作者：
Di Carlo, Dino;Edd, Jon F.;Toner, Mehmet
通讯作者：
Toner, Mehmet
DOI：
10.1073/pnas.0704958104
发表时间：
2007-11-27
影响因子：
11.1
作者：
Di Carlo, Dino;Irimia, Daniel;Toner, Mehmet
通讯作者：
Toner, Mehmet