High-frequency modulation of rat spinal field potentials: effects of slowly conducting muscle vs. skin afferents.
High-frequency modulation of rat spinal field potentials: effects of slowly conducting muscle vs. skin afferents.
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大鼠脊髓场电位的高频调制：缓慢传导肌肉与皮肤传入的影响
DOI：
10.1152/jn.00415.2015
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发表时间：
2016
影响因子：
2.5
通讯作者：
Treede RD
中科院分区：
文献类型：
--
作者：
Zhang J;Hoheisel U;Klein T;Magerl W;Mense S;Treede RD
高频电刺激大鼠脊髓背角传入C纤维可引起长时程增强（LTP）。LTP通常被认为是脊髓致敏的关键机制。为了确定皮肤和肌肉传入对LTP诱导的贡献，分别刺激腓肠神经（SU，纯皮肤神经）或腓肠肌-比目鱼肌神经（GS，纯肌肉神经）。作为脊髓LTP的测量，在背角中记录由GS和SU诱发的C纤维诱导的突触场电位（SFPs）。HFS诱导持续增加的SFP的同一神经至少3小时，表明同源突触伤害性脊髓LTP的启发。与皮肤神经刺激后的LTP（HFS应用于SU;增加至基线的151%，P < 0.05）相比，肌肉神经刺激后的LTP（HFS至GS）更明显（增加至248%，P <0.05）。HFS应用于GS也增加了非条件SU（异突触LTP）的SFP显着，而HFS应用于SU没有显着影响的SFP引起的GS。总的来说，数据表明肌肉或皮肤神经的HFS诱发伤害性脊髓LTP，同突触LTP具有大的效应量（Cohen'sdof0.8 -1.9），异突触LTP具有小到中等的效应量（Cohen' sdof0.4 -0.65）。HFS后的肌肉神经的同突触和异突触LTP比HFS后的皮肤神经的LTP更明显的发现表明，肌肉疼痛可能与更广泛的LTP比皮肤疼痛。
Long-term potentiation (LTP) in rat spinal dorsal horn neurons was induced by electrical high-frequency stimulation (HFS) of afferent C fibers. LTP is generally assumed to be a key mechanism of spinal sensitization. To determine the contribution of skin and muscle afferents to LTP induction, the sural nerve (SU, pure skin nerve) or the gastrocnemius-soleus nerve (GS, pure muscle nerve) were stimulated individually. As a measure of spinal LTP, C-fiber-induced synaptic field potentials (SFPs) evoked by the GS and by the SU were recorded in the dorsal horn. HFS induced a sustained increase of SFPs of the same nerve for at least 3 h, indicating the elicitation of homosynaptic nociceptive spinal LTP. LTP after muscle nerve stimulation (HFS to GS) was more pronounced (increase to 248%,P< 0.05) compared with LTP after skin nerve stimulation (HFS applied to SU; increase to 151% of baseline,P< 0.05). HFS applied to GS also increased the SFPs of the unconditioned SU (heterosynaptic LTP) significantly, whereas HFS applied to SU had no significant impact on the SFP evoked by the GS. Collectively, the data indicate that HFS of a muscle or skin nerve evoked nociceptive spinal LTP with large effect sizes for homosynaptic LTP (Cohen'sdof 0.8–1.9) and small to medium effect sizes for heterosynaptic LTP (Cohen'sdof 0.4–0.65). The finding that homosynaptic and heterosynaptic LTP after HFS of the muscle nerve were more pronounced than those after HFS of a skin nerve suggests that muscle pain may be associated with more extensive LTP than cutaneous pain.
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影响因子：
2.9
作者：
D. Moore;L. Kitzes
通讯作者：
D. Moore;L. Kitzes
组胺引起的瘙痒与实验性肌肉疼痛之间的相互作用
影响因子：
3.6
作者：
G. Wasner;K. Schwarz;J. Schattschneider;A. Binder;T. Jensen;R. Baron
通讯作者：
R. Baron
不同来源的 C 初级传入纤维在引起大鼠屈肌反射的长期促进方面的相对有效性
影响因子：
5.3
作者：
C. Woolf;P. Wall
通讯作者：
P. Wall
大鼠皮肤 C 纤维传入的河豚毒素抗性传导性和脊髓效应
影响因子：
2.9
作者：
H. Steffens;U. Hoheisel;B. Eek;S. Mense
通讯作者：
S. Mense
影响因子：
5.3
作者：
Fenselau, Henning;Heinke, Bernhard;Sandkuehler, Juergen
通讯作者：
Sandkuehler, Juergen