Pathogenesis of follicular thymic hyperplasia associated with rheumatoid arthritis.
Pathogenesis of follicular thymic hyperplasia associated with rheumatoid arthritis.
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DOI：
10.1111/pin.13212
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发表时间：
2022-04
影响因子：
2.2
通讯作者：
Futakuchi, Mitsuru
中科院分区：
文献类型：
--
作者：
Ohe, Rintaro;Yang, Suran;Yamashita, Daisuke;Ichikawa, Chihiro;Saito, Akihisa;Kabasawa, Takanobu;Utsunomiya, Aya;Aung, Naing Ye;Urano, Yuka;Kitaoka, Takumi;Suzuki, Kazushi;Takahara, Daiichiro;Sasaki, Akiko;Takakubo, Yuya;Takagi, Michiaki;Yamakawa, Mitsunori;Futakuchi, Mitsuru
关键词：
类风湿性关节炎（RA）患者在接受甲氨蝶呤治疗时可能会发生骨增生性疾病。然而，与RA相关的滤泡性胸腺增生（FTH）（FTH-RA）通常不被认为是淋巴组织增生性疾病。为了探讨FTH-RA的发病机制，我们检查了12例FTH涉及胸腺肿大，4例FTH涉及RA，8例FTH涉及重症肌无力（MG）。在FTH-RA组中观察到数量增加和较大的生发中心（GC）大小。变形GC的百分比在FTH-RA组中为13.3%，在FTH合并MG（FTH-MG）组中为3.25%。在FTH-RA组的GC中观察到更大的滤泡树突状细胞网络。FTH-RA组每个GC的CD 27+细胞和PD-1+细胞阳性指数显著高于FTH-MG组，但CD 68+细胞和CD 163+细胞阳性指数相似。通过α-SMA、腱生蛋白-C和l-钙调蛋白表达评估，与FTH-MG组相比，FTH-RA组的肌样细胞增殖显著增加。这些结果表明，FTH应考虑在RA患者与甲氨蝶呤治疗。FTH-RA的发病机制包括GC扩增和记忆B细胞、滤泡辅助性T细胞和肌样细胞数量增加，表明体液免疫激活。
Lymphoproliferative disorders may occur in patients with rheumatoid arthritis (RA) who are treated with methotrexate. However, follicular thymic hyperplasia (FTH) associated with RA (FTH‐RA) is generally not considered a lymphoproliferative disorder. To investigate the pathogenesis of FTH‐RA, we examined 12 cases of FTH involving thymic enlargement, four of FTH involving RA and eight of FTH involving myasthenia gravis (MG). Increased numbers and larger germinal center (GC) size were observed in FTH‐RA group. The percentage of distorted GCs was 13.3% in FTH‐RA group and 3.25% in FTH associated with MG (FTH‐MG) group. A greater meshwork of follicular dendritic cells was observed in the GCs of FTH‐RA group. Positive indices of CD27+ cells and PD‐1+ cells per GC in FTH‐RA group were significantly higher than those in FTH‐MG group, though positive indices of CD68+ cells and CD163+ cells were similar. Myoid cell proliferation, as evaluated by α‐SMA, tenascin‐C, and l‐caldesmon expression, was significantly increased in the FTH‐RA group compared with the FTH‐MG group. These results suggest that FTH should be considered in patients with RA treated with methotrexate. The pathogenesis of FTH‐RA includes GC expansion and increased numbers of memory B cells, follicular helper T cells, and myoid cells, indicating humoral immunity activation.
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影响因子：
4
作者：
Almudevar A
通讯作者：
Almudevar A
影响因子：
3.7
作者：
Aung NY;Ohe R;Meng H;Kabasawa T;Yang S;Kato T;Yamakawa M
通讯作者：
Yamakawa M
影响因子：
3.3
作者：
Ohe, Rintaro;Meng, Hong-Xue;Yamakawa, Mitsunori
通讯作者：
Yamakawa, Mitsunori
影响因子：
2.6
作者：
Suzuki, Kazushi;Ohe, Rintaro;Yamakawa, Mitsunori
通讯作者：
Yamakawa, Mitsunori
影响因子：
3.4
作者：
WAN, JH;TRAINOR, KJ;MORLEY, AA
通讯作者：
MORLEY, AA